Tapestri Single-cell DNA Chronic Lymphocytic Leukemia Panels
Chronic lymphocytic leukemia (CLL) is a genetically heterogeneous disease preceded by an asymptomatic expansion of clonal B-cells in a state known as high-count monoclonal B-cell lymphocytosis (MBL). Approximately 1-2% of high-count MBLs evolve into CLL each year. While significant gains have been made in our understanding of genetic mutations that contribute to an aggressive CLL disease state, identifying the biological and genetic events that determine which MBLs will progress to CLL is less understood. By gaining a better understanding of clonal evolution that drives the continuum from MBL to CLL, patient prognosis could be predicted long before CLL symptoms occur, and patients could receive regular disease monitoring and earlier treatment.
Advance your understanding of the genetic heterogeneity underpinning chronic lymphocytic leukemia (CLL) by targeting 32 genes with 274 amplicons for single-cell sequencing. Covering a combination of oncogenes and tumor suppressor genes, this panel is designed to cover some of the most commonly mutated genes associated with CLL.
Single-Cell Genomics Studies in Monoclonal B-Cell Lymphocytosis and Chronic Lymphocytic Leukemia.
Esteban Braggio, PHD, Mayo Clinic Arizona
Single-Cell DNA Sequencing Resolves the Genetic Complexity Underlying CLL Progression.