AACR 2019

March 29 – April 3, 2019
Georgia World Congress Center
Booth #2850

Spotlight Theater REGISTER
Precision Sequencing with Single-Cell Genomics: Resolving Genetic Heterogeneity in Blood and Solid Tumors
Monday, April 1   3:00 – 4:00PM   Exhibit Theater B

Precision Sequencing with Single-Cell Genomics: Resolving Genetic Heterogeneity in Blood and Solid Tumors
Introduction: Nigel Beard, PhD, SVP Research & Development, Mission Bio
Unraveling Clonal Heterogeneity and Evolutionary History of AML by Single-Cell DNA Sequencing
Koichi Takahashi, MD, Assistant Professor, MD Anderson Cancer Center
Single-Cell Genomics Studies in MBL and CLL
Esteban Braggio, PhD, Assistant Professor of Medicine, Mayo Clinic Arizona

Intra-tumor heterogeneity is a common feature of many cancers and is correlated with poor clinical outcomes. Detection of rare tumor subclones, uniquely defined by mutational co-occurrence within single cells, has the potential to better predict disease progression and inform therapy selection. Join Mission Bio to hear from these thought leaders on how the Tapestri® Platform is scaling to address critical needs in oncology research.

POSTERS and SESSIONS
Analytical Methods to Identify Tumor Heterogeneity and Rare Subclones in Single-Cell DNA Sequencing Data from Targeted Panels

Date: Monday, April 1, 2019

Time: 8:00am - 12:00pm

Location: Exhibit Hall B, Poster Section 31

Abstract 1663

Presenters: Shu Wang, Sr. Bioinformatics Scientist, Mission Bio

High-Throughput Single-Cell Targeted DNA Sequencing from Frozen, Fixed, and Preserved Solid Tumor Samples Reveals Complex Genomic Variation and Clonal Propagation

Date: Monday, April 1, 2019

Time: 1:00pm - 5:00pm

Location: Exhibit Hall B, Poster Section 33

Abstract 2532

Presenters: Dave Ruff, Senior Director, Mission Bio

SYPOL04 - Differentiation Syndrome in Acute Myeloid Leukemia: Challenges for Drug Development and Regulation

Date: Monday, April 1, 2019

Time: 1:00pm - 2:45pm

Location: Room A402

Presenters: Feng Wang, UT MDAnderson Cancer Center, Houston, TX

The single-cell atlas of driver mutations in acute myeloid leukemia

Date: Monday, April 1, 2019

Time: 4:05 PM - 4:20 PM

Location: Room A302

Abstract 2725

Presenters: Kiyomi Morita, MD Anderson Cancer Center

A Complete Solution for High-Throughtput Single-Cell Targeted Multiomic DNA and RNA Sequencing for Cancer Research

Date: Tuesday, April 2, 2019

Time: 8:00am - 12:00pm

Location: Exhibit Hall B, Poster Section 36

Abstract 3540

Presenters: Dalia Dhingra, SeniorScientist, Mission Bio

Session PO.MCB09.05 - High-throughput Sequencing Combined high-throughput DNA genotyping and protein quantification in single cancer cells

Date: Tuesday, April 2, 2019

Time: 8:00 AM - 12:00 PM

Location: Exhibit Hall B, Poster Section 33

Abstract 3527

Presenters: Benjamin Demaree, University of California, San Francisco, and Dave Ruff, Mission Bio

High-Throughput Single-Cell Targeted DNA Sequencing Using an Updated Tapestri Platform Reveals Rare Clones and Clonal Evolution for Multiple Blood Cancers

Date: Wednesday, April 3, 2019

Time: 8:00am - 12:00pm

Location: Exhibit Hall B, Poster Section 9

Abstract 4696

Presenters: Nianzhen Li, Director,Mission Bio

Single-Cell Mutational Profiling of Paired AML Samples at Diagnosis, Remission, and Relapse: Implications for Therapeutic Resistance and MRD Detection

Date: Wednesday, April 3, 2019

Time: 8:00am - 12:00pm

Location: Exhibit Hall B, Poster Section 32

Abstract 5130

Presenters: Alex Aleshin, Adjunct Clinical Professor, Stanford University and Dennis Eastburn, CSO, Mission Bio