Home Applications Oncology Research Solid Tumors

Solid Tumor Profiling

Because understanding cancer’s mechanisms and therapy resistance requires single-cell insights

A major challenge to combating cancer is the tumor’s inherent heterogeneity. Single-cell DNA sequencing allows you to unmask the underlying genetic diversity across cell populations and gain insights into the clonal architecture, mutation co-occurrence, and rare mutations driving tumor progression and therapy resistance.

TALK TO A SCIENTIST

NEW: Check out the latest Tapestri Platform updates for solid tumor research.

LEARN MORE

Why Single Cell for Solid Tumor Applications?

Single-cell DNA sequencing enables you to analyze SNVs, indels, CNVs, and LOH and unambiguously identify variant zygosity, mutational co-occurrence, and rare mutations in thousands of individual cells. With these in-depth insights, solid tumor researchers can elucidate the mechanisms of drug resistance through mutation acquisition, determine how cells transform from benign to malignant states, and reveal the genomic changes enabling cancer cells to metastasize.

It is time to look at the sources of malignancies

Track clonal evolution at different metastasis sites

Track clonal evolution and reconstruct phylogenetic trees

Single-cell DNA analysis with the Tapestri Platform and nuclei from metastatic melanoma tissue

Dr. Charlie Swanton, Francis Crick Institute

VIEW APP NOTE

Uncover zygosity and co-occurence of mutations in solid tumor profiling

V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer

Dr. Jorge S. Reis-Filho

VIEW PAPER

Measure gene and chromosome-level CNVs along with SNVs/indels and protein expression

Measure gene and chromosome arm-level CNVs along with SNVs and indels

Copy number variants and single nucleotide variants simultaneously detected in single cells

Dr. Charlie Swanton, Francis Crick Institute

VIEW APP NOTE

Solid Tumor Panels

Order a predesigned solid tumor panel or customize any panel with your own targets of interest

Select panel content relevant to your specific applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. Mission Bio offers several catalog and virtual panels for solid tumor profiling that are designed based on evidence from public databases and cover some of the most clinically relevant genes.

Available DNA Panels

Ready-to-Ship

Tapestri Single-cell DNA Catalog Panel

Predesigned and ready-to-ship panels covering the most commonly implicated genes in solid tumor cancer and wet lab-tested to assure performance.

Build-to-Order

Tapestri Single-cell DNA Virtual Design Panels

Predesigned and build-to-order panels for additional indications in solid tumors.

Breast Cancer

Glioma

Tumor Hotspot

Tapestri Single-cell DNA Custom Panels

Fully customizable panels for maximum flexibility. Easily order a custom panel using Tapestri Designer.

Learn More

See how single-cell DNA sequencing uncovers resistance mechanisms for MEK and EGFR inhibitors in colon cancer.

Jorge Reis-Filho, MD, PhD, Memorial Sloan Kettering Cancer Center

VIEW PUBLICATION

CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

Single-cell Genomics (DNA)

SNV

Detect rare clonal populations and identify co-occurrence and zygosity.

LEARN MORE

SNV + CNV

Characterize genomic heterogeneity using a single comprehensive platform.

LEARN MORE

Single-cell Multi-omics (DNA+)

DNA + Protein

Gain a true multi-omics picture from genotype to phenotype.

LEARN MORE

Other APPLICATIONS