Posters | Mission Bio

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Single-cell Multi-omics Analysis Reveals Differential Lineage-specific Vector Copy Number Distribution in CAR-T Cell Products

Yilong Yang; Saurabh Parikh; Khushali Patel; Qawer Ayaz; Lindsey Murphy; Amanda Winters; Terry J. Fry; Mahir Mohiuddin; Hua-Jun He; John Elliott; Benjamin Schroeder; Shu Wang; Chieh-Yuan (Alex) Li

ESGCT 2024 (2024)

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High Throughput Single-cell Assessment of Genome Integrity and Toxicity Events Associated With Edited Cells

Chieh-Yuan (Alex) Li; Saurabh Parikh; Saurabh Gulati; Donjo Ban; Nechama Kalter; Michael Rosenburg; Qawer Ayaz; Joanne Nguyen; Benjamin Miltz; Yang Li1; Madhumita Shrikhande; Edward Szekeres; Ayal Hendel; Benjamin Schroeder; Shu Wang

ESGCT 2024 (2024)

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Single-cell Multiomic Clonal Tracking in Myeloma Identifies SMM Clones that Progress to MM and Low-Frequency MM Clones with Resistance Features Enabling More Precise Application of Targeted Therapies

Adam Sciambi

ISEH (2024)

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A novel single-cell measurable residual disease (scMRD) assay for simultaneous DNA mutation and surface immunophenotype profiling

Holly Tillson

ISEH (2024)

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Single-cell multiomic clonal tracking in myeloma identifies SMM clones that progress to MM and low frequency MM clones with resistance features enabling more precise application of targeted therapies.

Adam Sciambi

EHA (2024)

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High Throughput Single Cell Analysis Workflow for Accurate Measurement of Genotoxicity Arising from Gene Editing Experiments

Saurabh Gulati

ASGCT (2024)

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Navigating Heterogeneity in Genome Editing Outcomes Using Single-cell Analysis

Brittany Enzmann

ASGCT (2024)

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Single-Cell Multi-Omic Correlation of Single Nucleotide Variants, Copy Number Variation, and Surface Epitopes for Clonal Profiling of Myeloma

Adam Sciambi; Indira Krishnan; Ben Geller; Daniel Mendoza; Chenchen Yang; Charlie Murphy; Cedric Dos Santos; Vivek S. Chopra; Habib Hamidi; Michael Nixon; Yann Nouet; Todd Druley; Herve Avet-Loiseau

ASH (2023)

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Decoding the mosaicism of genome editing with single-cell multi-omics analysis

Saurabh Gulaiti

ESGCT (2023)

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Single-Cell Multi-Omic Correlation of Single Nucleotide Variants, Copy Number Variation, and Surface Epitopes for Clonal Profiling of Myeloma

Adam Sciambi, Cedric Dos Santos, Vivek S. Chopra, Habib Hamidi, Michael Nixon, Yann Nouet, Todd Druley, Herve Avet-Loiseau

International Myeloma Society (2023)

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A Multiomic, Single-Cell Measurable Residual Disease (scMRD) Assay For Phasing DNA Mutations and Surface Immunophenotypes

Charlie Murphy

Nordic AML Meeting (2023)

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Quantification of Single Cell Vector Copy Number in CAR T Cell Products Utilizing a Novel Microfluidic Technology

Benjamin Schroeder

ASGCT (2023)

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Precise Measurement of Viral Copy Number at Single-Cell Resolution for Cell and Gene Therapy Development

Chieh-Yuan Li

ASGCT (2023)

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Single-Cell Lentiviral Vector Integration Sites and Clonal Tracking Assay for Cell and Gene Therapy

Shu Wang

ASGCT (2023)

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Precise Measurement of Viral Copy Number at Single-Cell Resolution for Cell and Gene Therapy Development

Matthew Cato

GTAD (2023)

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Utilization of the Tapestri Platform for Quantification of Single Cell Vector Copy Number in CAR T Cell Products

Lindsey Murphy

ASH 2022 (2023)

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Precise Measurement of Viral Copy Number at Single-Cell Resolution for Cell and Gene Therapy Development

Yue Wang

(2022)

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Leveraging Single-cell DNA Sequencing for In-depth Characterization of Cell and Gene Therapies

Jacqueline Marin, Benjamin Schroeder, Shu Wang, Daniel Mendoza, Adam Sciambi, Brittany Enzmann

ISCT (2022)

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Multimodal Analysis of DNA and Proteins in Single Cells

Prithvi Singh, Dalia Dhingra, Saurabh Parikh, Adam Sciambi, Aik Ooi

EACR (2022)

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Precise Measurement of Transduction Efficiency at Single-Cell Resolution for Cell and Gene Therapy Development

Khushali Patel

ASGCT (2022)

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Enabling single cell analysis of copy number variation in breast cancer

Jacqueline Marin

AACR (2022)

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Linking phenotype and genotype: multimodal analysis of surface proteins, intracellular proteins, and SNVs in single cells

Aik Ooi

AACR (2022)

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Single-cell multi-omic analysis of SNV, CNV, and protein expression

Aik Ooi

AACR (2021)

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A multimodal single-cell workflow to interrogate cellular responses to cancer therapy

Dalia Dhingra

AACR (2021)

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Method to analyze mutational and phenotypic profiles from single cell for clonal evolution

Saurabh Parikh

AACR (2021)

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Amplicon design algorithm for single cell targeted DNA sequencing using machine learning

Shu Wang

AACR (2020)

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Improvements in variant calling sensitivity and specificity in single-cell DNA sequencing using deep learning

Manimozhi Manivannan

AACR (2020)

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Powerful insights with single-cell multi-omics: Co-detecting both genotype and phenotype from the same cell

James Flynn, PhD

AGBT (2020)

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Subclonal identification of driver mutations and copy number variations from single-cell DNA sequencing of tumors

James Flynn, PhD

ABRF (2020)

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Single-cell multi-omics for simultaneous detection of SNVs, CNVs, and proteins using the Tapestri Platform

Aik Ooi, PhD

AMP (2019)

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An automated high-throughput custom single-cell targeted DNA sequencing platform to reveal rare clonal evolution in cancer and characterize mutation profiles in CRISPR edited cells

Daniel Mendoza

ASHG (2019)

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Single-cell simultaneous detection of DNA genotype and protein expression

Aik Ooi, PhD

SCG (2019)

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Error correction in single-cell DNA sequencing: finding rare allele for MRD clone

Kim Dong, MS

SCG (2019)

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An automated high-throughput custom single-cell targeted DNA sequencing platform to reveal rare clonal evolution in cancer and characterize mutation profiles in CRISPR edited cells

Adam Sciambi

SCG (2019)

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Using machine learning to optimize assays for single-cell targeted DNA sequencing

Nianzhen Li

SOHO (2019)

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Methods to detect large indels and tandem duplication in acute myeloid leukemia using single-cell DNA sequencing

Sombeet Sahu, MS

ISMB (2019)

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Analytical methods to identify tumor heterogeneity and rare subclones in single-cell DNA sequencing data from targeted panels

Sombeet Sahu, MS

ISMB (2019)

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High-throughput Single-cell Targeted DNA Sequencing from Frozen, Fixed and Preserved Solid Tumor Samples Reveals Complex Genomic Variation and Clonal Propagation

Pedro Mendez

AACR (2019)

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High-throughput single-cell targeted DNA sequencing using an updated Tapestri platform reveals rare clones and clonal evolution for multiple blood cancers

Nianzhen Li

AACR (2019)

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Analytical methods to identify tumor heterogeneity and rare subclones in single-cell DNA sequencing data from targeted panels

Manimozhi Manivannan

AACR (2019)

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Highly robust and sensitive off-the-shelf and custom cancer solutions for high-throughput single-cell targeted DNA sequencing

Kathryn Thompson

AGBT (2019)