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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
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Solid Tumors.

Because understanding cancer’s mechanisms and therapy resistance requires single-cell insights

A major challenge to combating cancer is the tumor’s inherent heterogeneity. Single-cell DNA sequencing allows you to unmask the underlying genetic diversity across cell populations and gain insights into the clonal architecture, mutation co-occurrence, and rare mutations driving tumor progression and therapy resistance.

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NEW: Check out the latest Tapestri Platform updates for solid tumor research.

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Why Single Cell for Solid Tumor Applications?

Single-cell DNA sequencing enables you to analyze SNVs, indels, CNVs, and LOH and unambiguously identify variant zygosity, mutational co-occurrence, and rare mutations in thousands of individual cells. With these in-depth insights, solid tumor researchers can elucidate the mechanisms of drug resistance through mutation acquisition, determine how cells transform from benign to malignant states, and reveal the genomic changes enabling cancer cells to metastasize.

It is time to look at the sources of malignancies

Track clonal evolution at different metastasis sites
Track clonal evolution and reconstruct phylogenetic trees
Single-cell DNA analysis with the Tapestri Platform and nuclei from metastatic melanoma tissue

Dr. Charlie Swanton, Francis Crick Institute
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Uncover zygosity and co-occurence of mutations in solid tumor profiling
Uncover zygosity and co-occurence of mutations in solid tumor profiling
V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer

Dr. Jorge S. Reis-Filho
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Measure gene and chromosome-level CNVs along with SNVs/indels and protein expression
Measure gene and chromosome arm-level CNVs along with SNVs and indels
Copy number variants and single nucleotide variants simultaneously detected in single cells

Dr. Charlie Swanton, Francis Crick Institute
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Solid Tumor Panels

Order a predesigned solid tumor panel or customize any panel with your own targets of interest

Select panel content relevant to your specific applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. Mission Bio offers several catalog and virtual panels for solid tumor profiling that are designed based on evidence from public databases and cover some of the most clinically relevant genes.

Available DNA Panels
Ready-to-Ship
Tapestri Single-cell DNA Catalog Panel
Predesigned and ready-to-ship panels covering the most commonly implicated genes in solid tumor cancer and wet lab-tested to assure performance.
Tumor Hotspot
Build-to-Order
Tapestri Single-cell DNA Virtual Design Panels
Predesigned and build-to-order panels for additional indications in solid tumors.
Breast Cancer
Glioblastoma Multiforme
Tapestri Single-cell DNA Custom Panels
Fully customizable panels for maximum flexibility. Easily order a custom panel using Tapestri Designer.
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See how single-cell DNA sequencing uncovers resistance mechanisms for MEK and EGFR inhibitors in colon cancer.

Jorge Reis-Filho, MD, PhD, Memorial Sloan Kettering Cancer Center

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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

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Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Hematologic Malignancies
Clonal evolution impacts response, resistance, relapse, and residual disease.
Genome Editing
Precision tools provide quality control, ensuring the appropriate edits are incorporated.

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