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SNV

Untangle Single-cell SNV and Indel Insights.

The Tapestri Platform is the first and only single-cell multi-omics platform to simultaneously detect single nucleotide variants (SNVs) and indels from the same cell. Move beyond the average readout from conventional bulk sequencing, and uncover the underlying heterogeneity and rare cell populations in cancer research samples.

Why Single Cell for SNVs and Indels?

The average readout from conventional bulk sequencing misses the underlying genetic diversity across cell populations. Single-cell DNA sequencing for single nucleotide variants and indels provides the true measure of clonal heterogeneity without inferring or guessing. Reveal the true clonal architecture in a tumor sample without the assumptions confounded by bulk sequencing.

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Identify true mutation co-occurrence in clonal populations.
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Detect rare subclones down to 0.1% that may be missed by bulk sequencing.
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Determine the zygosity that matters for your disease research.

See how single-cell DNA sequencing reveals clonal evolution in AML patients on gilteritinib.

Cathy Smith, M.D., University of California, San Francisco

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Target the diversity that matters with content in a custom panel, or start with one of our pre-designed panels.
Explore Hematology
See how single-cell DNA sequencing transforms the study of hematological malignancies.

The Tapestri Workflow

Integrate seamlessly into your existing NGS workflow with sample prep and analysis solutions using the Tapestri single-cell sequencing platform

With our single-cell sequencing platform, use the Tapestri Instrument, reagents, and consumables up-front of your NGS system and then Tapestri Pipeline and Tapestri Insights software for data analysis and visualization.
Target Selection
Choose a pre-designed or custom DNA panel
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LIBRARY
PREP
Single workflow combines DNA and protein panels
Tapestri Platform icon
SEQUENCING
Single sequencing run for multi-omics single-cell data
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PIPELINE
Integrated pipeline for multi-omics analysis
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ANALYSIS
Powerful analysis and visualization software
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Datasets

Explore the datasets below using single-cell DNA analysis for single nucleotide variants

NAME
DESCRIPTION
LAST UPDATED

Sample dataset for the Tapestri Single Cell DNA AML panel

10.23.2019

Sample dataset for the Tapestri Single Cell DNA Myeloid panel

10.23.2019

Sample dataset for the Tapestri Single Cell DNA CLL panel

10.23.2019

Sample dataset for a 4-cell line mixed experiment using the Tapestri Single-Cell DNA AML panel

10.23.2019
OTHER CAPABILITIES

DNA Is Our Foundation

Providing cancer specialists with the only single-cell targeted DNA solution that integrates CNV, SNV, and protein data from the same cell.

Single-cell Genomics (DNA)
SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Use Tapestri Designer to design a custom panel tailored to your needs.

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