Bridge the Gap Between Mutation and Expression

The Tapestri^® Single-Cell Targeted DNA + RNA Assay delivers a multidimensional view of each cell, linking genotype to phenotype to reveal how genetic variation shapes RNA expression. From complex cancers to engineered cell therapies, Tapestri empowers researchers to uncover mechanisms of action, validate therapeutic edits, and accelerate the path to precision medicine.

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Why Targeted DNA + RNA Single-Cell Analysis?

By integrating targeted DNA genotyping with RNA expression profiling, you can confidently pinpoint disease-driving variants, uncover resistance mechanisms, and characterize engineered cell populations — all from the same cells.

Refine Disease Classification and Mechanistic Insight

Combine somatic mutation and expression profiles to distinguish subclones, identify driver mutations, and reveal dysregulated pathways driving disease progression.

Accelerate Biomarker and Drug Target Discovery

Link genomic variants to functional RNA readouts to confirm target expression, uncover actionable biomarkers, and validate therapeutic mechanisms.

Advance Cell and Gene Therapy Characterization

Correlate gene editing outcomes and vector copy number with transcriptional changes to verify on-target activity, assess efficacy, and ensure functional validation.

Applications

Oncology

Tumor Classification & Clonal Subtyping

Combining somatic mutation profiles (DNA) with transcriptional signatures (RNA) allows more precise stratification of cancers

Identifying Driver Mutations & Pathway Dysregulation

DNA reveals recurrent driver mutations, and RNA shows their influence on regulatory pathways

Predicting Therapy Response

RNA analysis can reveal alternative splicing, pathway rewiring, or activation of bypass signaling

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Target Discovery & Rare Disease

Drug Target Discovery & Biomarker Development

DNA detects mutations targetable by drugs and RNA validates that the gene is actually expressed, contributing to the disease state

Rare Genetic & Inherited Disorders

Many rare disorders arise from post-zygotic DNA mutations present in only a subset of cells. Multi-omics can connect the DNA mutation to aberrant RNA signatures.

Therapy Response & Mechanism of Action

RNA profiling can reveal whether a therapy achieves its intended effects by monitoring upregulation or inhibition of target genes, providing a direct readout of functional impact.

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The Single-Cell Targeted DNA + RNA Assay

Tapestri^® Single-Cell DNA Core Kit v3
Tapestri^® Targeted RNA Expression Kit v3
Tapestri^® Single-Cell DNA Cartridge Kit v3
Tapestri^® Single-Cell DNA Panel
Catalog or Custom Panel
Tapestri^® Single-Cell Clonal Insights Software 2.0 – On Premise
Tapestri^® Targeted RNA Expression Catalog Panel
Tapestri^® Targeted RNA Expression Custom Panel

Translate Insight Into Action With Fully Interpreted Results

This experiment highlights the power of Tapestri and its ability to distinguish cell types in cell lines and PBMCs. T47D (breast cancer) and A549 (lung cancer) were chosen to highlight the variable genotypic profiles of each disease, while PBMCs were included to show how granularly the cell types within the sample type could be distinguished and categorized.

Figure 1: The ‘Genotype’ subplot displays cells from the multiplexed run, colored according to their genotype-level information derived from genotype demultiplexing, which identifies samples based on genotype variants. The ‘RNA Cell Type’ subplot shows the same cells colored by clustering results obtained from gene expression profiles of the targeted gene panel or probes.

Bridge the Gap Between Mutation and Expression

Why Targeted DNA + RNA Single-Cell Analysis?

Applications

Oncology

Target Discovery & Rare Disease

Workflow

Tapestri Single-Cell DNA + RNA Workflow

The Single-Cell Targeted DNA + RNA Assay

Translate Insight Into Action With Fully Interpreted Results

Resources

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