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An automated high-throughput custom single-cell targeted DNA sequencing platform to reveal rare clonal evolution in cancer and characterize mutation profiles in CRISPR edited cells

Daniel Mendoza

Many stages of hematopoietic differentiation provide multiple opportunities for mutations that lead to distinct tumor subtypes. However, standard bulk population sequencing is hard to identify rare alleles or determine whether multiple mutations co-occur within the same cell.

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An automated high-throughput custom single-cell targeted DNA sequencing platform to reveal rare clonal evolution in cancer and characterize mutation profiles in CRISPR edited cells

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