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Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer

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Distinct patterns of clonal evolution drive myelodysplastic syndrome progression to secondary acute myeloid leukemia

Blood Cancer Discovery (2022)

High-throughput single-cell sequencing for retroviral reservoir characterization

scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells

Monitoring of leukemia clones in B-cell acute lymphoblastic leukemia at diagnosis and during treatment by single-cell DNA amplicon sequencing

HemaSphere (2022)

Single-cell analysis reveals selection of TP53-mutated clones after MDM2 inhibition

Blood Advances (2022)

Application of high-throughput, high-depth, targeted single-nucleus DNA sequencing in pancreatic cancer

Developmental venous anomalies are a genetic primer for cerebral cavernous malformations

Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL

Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

Reconstructing mutational lineages in breast cancer by multi-patient-targeted single cell DNA sequencing

Mechanisms of resistance to noncovalent Bruton’s tyrosine kinase inhibitors

New England Journal of Medicine (2022)

Molecular characterization of acquired resistance to KRAS G12C inhibition in gastrointestinal cancers

Research Square (2022)

Preneoplastic somatic mutations including MYD88L265P in lymphoplasmacytic lymphoma

Science Advances (2022)

Single-cell sequencing demonstrates complex resistance landscape in CLL and MCL treated with BTK and BCL2 inhibitors

Blood Advances (2021)

Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue

Diverse alterations associated with resistance to KRAS(G12C) inhibition

Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes

Nature Medicine (2021)

Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma

Marin-Bejar, O.

Cancer Cell (2021)

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias

Personalized single-cell proteogenomics to distinguish acute myeloid leukemia from nonmalignant clonal hematopoiesis

Blood Cancer Discovery (2021)