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A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN.

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Modeling and targeting of erythroleukemia by hematopoietic genome editing

A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN.

Blood Advances (2020)

Single-cell mutation analysis of clonal evolution in myeloid malignancies.

Leukemia stemness and co-occurring mutations drive resistance to IDH inhibitors in acute myeloid leukemia

Personalized Single-Cell Proteogenomics to Distinguish Acute Myeloid Leukemia from Non-Malignant Clonal Hematopoiesis

Laura W. Dillon

Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.

Nature Communications (2020)

High throughput single-cell detection of multiplex CRISPR-edited gene modifications.

Genome Biology (2020)

Single-cell genomics reveals the genetic and molecular bases for escape from mutational epistasis in myeloid neoplasms.

Detectable mutations precede late myeloid neoplasia in aplastic anemia.

Haematologica (2020)

Single-cell DNA amplicon sequencing reveals clonal heterogeneity and evolution in T-cell acute lymphoblastic leukemia.

Albertí-Servera, L.

Clonal independence of JAK2 and CALR or MPL mutations in co-mutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing.

Haematologica (2020)

Biological and clinical significance of dysplastic hematopoiesis in patients with newly diagnosed multiple myeloma.

Distinct genetic pathways define pre-leukemic and compensatory clonal hematopoiesis in Shwachman-Diamond syndrome

Molecular mechanisms mediating relapse following ivosidenib monotherapy in IDH1-mutant relapsed or refractory AML.

Blood Advances (2020)

Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML.

Single-cell mutational profiling enhances the clinical evaluation of AML MRD.

Ediriwickrema, A.

Blood Advances (2020)

Joint profiling of proteins and DNA in single cells reveals extensive proteogenomic decoupling in leukemia

V211D Mutation in MEK1 Causes Resistance to MEK Inhibitors in Colon Cancer.

Cancer Discovery (2019)

Polyclonal Heterogeneity: The New Norm for Secondary Clinical Resistance to Targeted Monotherapy in Relapsed Leukemia?

Cancer Discovery (2019)

Clonal Selection with RAS Pathway Activation Mediates Secondary Clinical Resistance to Selective FLT3 Inhibition in Acute Myeloid Leukemia.

Cancer Discovery (2019)