Publications

Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib

Peretz CAC, McGary LHF, Kumar T, Jackson H, Jacob J, Durruthy-Durruthy R, Levis MJ, Perl A, Huang BJ, Smith CC

Blood Advances Mar 2021

Abstract

Single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib. Single-cell sequencing reveals on- and off-target mechanisms of resistance to quizartinib, which can preexist therapy.

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Area

Heme

Institution Type

Academia

Indication / Modality

Acute Myleoid Leukemia (AML)

Goal of Study

Therapeutic Resistance, Clonal Evolution, Longitudinal, Clonal Heterogeneity

Key Genes

FLT3, RAS, KIT

PAD Project

Analytes Assessed

SNV, InDels

Sample Storage

Fresh Frozen

Sample Prep

Whole Cells

Sample Type

Patient Material, PBMC

Tissue / Organ

Bone Marrow Aspirates

Species

Human

Panel Used

Custom

Proof Point Demonstrated

Co-occurrence, Clonality, Better than Bulk

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