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technical note

AML subpopulations defined by SNV, CNV, and protein expression

Cancer is a heterogeneous mixture of cells with varied states. The best treatment options require an understanding of the disease state at the cellular level. Single-cell multi-omics reveals the interplay between genotype and phenotype. The Tapestri Platform is the only single-cell multi-omics platform capable of simultaneously detecting SNVs, CNVs, and protein expression from the same single cell. Bulk sequencing, cell-line databases, and flow cytometry were orthogonally verified against Tapestri multi-omics results.


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In-depth quantification of cell and gene therapy DNA integrations enabled with single-cell sequencing
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Deep understanding of cell and gene therapy genome editing protocols enabled with single-cell sequencing
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Model organisms and patient-derived xenografts for preclinical oncology research
technical note
Correlations between genomic variants and protein expression in AML patient samples
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