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technical note

Single-cell DNA sequencing resolves the genetic complexity underlying CLL progression

Co-occurrence and zygosity of mutations in subclonal populations are frequently missed with bulk sequencing. In high-count monoclonal B-cell lymphocytosis (MBL), these mutations were detectable across all patient samples, on average 41 months prior to chronic lymphocytic leukemia (CLL) progression as a result of single-cell analysis. Learn how the Tapestri Single-cell DNA CLL Panel was used to both gain further insights into patient samples and correlated with a deep targeted sequencing approach.


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technical note
Model organisms and patient-derived xenografts for preclinical oncology research
technical note
Correlations between genomic variants and protein expression in AML patient samples
technical note
AML subpopulations defined by SNV, CNV, and protein expression
technical note
Copy number variants (CNV) and single nucleotide variants (SNV) simultaneously detected in single cells
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