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technical note

Single-cell DNA sequencing resolves the genetic complexity underlying CLL progression

Co-occurrence and zygosity of mutations in subclonal populations are frequently missed with bulk sequencing. In high-count monoclonal B-cell lymphocytosis (MBL), these mutations were detectable across all patient samples, on average 41 months prior to chronic lymphocytic leukemia (CLL) progression as a result of single-cell analysis. Learn how the Tapestri Single-cell DNA CLL Panel was used to both gain further insights into patient samples and correlated with a deep targeted sequencing approach.


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technical note
In-depth quantification of cell and gene therapy DNA integrations enabled with single-cell sequencing
technical note
Deep understanding of cell and gene therapy genome editing protocols enabled with single-cell sequencing
technical note
Model organisms and patient-derived xenografts for preclinical oncology research
technical note
Correlations between genomic variants and protein expression in AML patient samples
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