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technical note

Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia (AEL) CRISPR Induced Mouse Model

Acute erythroid leukemia (AEL) is a high-risk form of acute myeloid leukemia, but models of this rare disease are lacking. In this application note, CRISPR and single-cell DNA sequencing are used to generate and analyze mouse models of AEL. Single-cell analysis of serially transplanted tumors revealed the clonal structure and co-mutations responsible for tumorigenesis.

The following are covered:

  • Assessment of precise genetic edits
  • Analysis of the clonal structure & co-mutations of AEL
  • Use of CRISPR and scDNA-seq for disease modeling


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