Solid tumors often show multiple levels of heterogeneity, including heterogeneity at different locations within the body, spatial heterogeneity within a single solid tumor, and cell-to-cell heterogeneity within the same slice of solid tumor. To explore this heterogeneity further, single-cell DNA-seq reveals the zygosity and co-occurrence of mutations within different clones so that phylogenetic analysis can be reconstructed, and tumor evolution is better understood.
LEARN MOREMetastatic cancer in solid tumors leads to the clonal evolution of mutations at different sites in the body. Understanding the phylogeny of mutations at different cancer sites reveals how the metastases developed and is easily reconstructed with single-cell DNA-seq. Zygosity and co-occurrence of the mutations within the clones are revealed. In addition, along with SNVs and indels, CNVs, and protein expression give a detailed picture of the nature of each individual cancer cell.
See how single-cell DNA sequencing applications reveal SNV/indel, CNV, and protein multi-omics data from thousands of cells
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Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels for solid tumor malignancies based on public databases and actionable clinical targets.
Custom Panels
Custom designs with Tapestri DesignerProviding cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.
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