Because clonal phylogeny and rare cell detection contribute to disease evolution
Solid tumors often show multiple levels of heterogeneity. This heterogeneity can contribute to molecular lesions play a role in driving cancer evolution and treatment response. With single-cell DNA sequencing, you can discern each patient’s response profile to better study therapy response, resistance, and relapse.
Metastatic cancer in solid tumors leads to the clonal evolution of mutations at different sites in the body. Understanding the phylogeny of mutations at different cancer sites reveals how the metastases developed and is easily reconstructed with single-cell DNA-seq. Zygosity and co-occurrence of the mutations within the clones are revealed. In addition, along with SNVs and indels, CNVs, LOH, and protein expression give a detailed picture of the nature of each individual cancer cell.
It is time to look at the sources of maligancies
Track clonal evolution and reconstruct phylogenetic trees
Single-cell DNA analysis with the Tapestri Platform and nuclei from metastatic melanoma tissue
Order a predesigned solid tumor panel or customize any panel with your own targets
Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels for solid tumor profiling based on public databases and actionable clinical targets.
Available DNA Panels
Tapestri Single-cell DNA Catalog Panel
Predesigned and ready-to-ship panels covering the most commonly implicated genes in solid tumor cancer and wet lab-tested to assure performance.