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Solid Tumor

Because clonal phylogeny and rare cell detection down to 0.1% make a difference.

Solid tumors often show multiple levels of heterogeneity, including heterogeneity at different locations within the body, spatial heterogeneity within a single solid tumor, and cell-to-cell heterogeneity within the same slice of solid tumor. To explore this heterogeneity further, single-cell DNA-seq reveals the zygosity and co-occurrence of mutations within different clones so that phylogenetic analysis can be reconstructed, and tumor evolution is better understood.

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Why Single Cell for Solid Tumor Applications?

Metastatic cancer in solid tumors leads to the clonal evolution of mutations at different sites in the body. Understanding the phylogeny of mutations at different cancer sites reveals how the metastases developed and is easily reconstructed with single-cell DNA-seq. Zygosity and co-occurrence of the mutations within the clones are revealed. In addition, along with SNVs and indels, CNVs, and protein expression give a detailed picture of the nature of each individual cancer cell.

See how single-cell DNA sequencing applications reveal SNV/indel, CNV, and protein multi-omics data from thousands of cells

Track clonal evolution at different metastasis sites
Track clonal evolution at different metastasis sites
Single-cell DNA analysis with the Tapestri Platform and nuclei from metastatic melanoma tissue
Dr. Charlie Swanton , Francis Crick Insititute
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Uncover zygosity and co-occurence of mutations in solid tumors
Uncover zygosity and co-occurence of mutations in solid tumors
V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer
Dr. Jorge S. Reis-Filho
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Measure gene and chromosome-level CNVs along with SNVs/indels and protein
Measure gene and chromosome-level CNVs along with SNVs/indels and protein
Copy number variants and single nucleotide variants simultaneously detected in single cells
Dr. Charlie Swanton , Francis Crick Institute
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Solid Tumor Panels

Order a catalog solid tumor panel or customize any panel with your own targets

Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels for solid tumor malignancies based on public databases and actionable clinical targets.

Available Panels
CUSTOM PANELS
Order a catalog panel as is, or easily add or subtract content to customize your research to your specific sequencing applications using Tapestri Designer.
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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Hematology
Clonal evolution impacts response, resistance, relapse, and residual disease.
Genome Editing
Precision tools provide quality control, ensuring the appropriate edits are incorporated.

Featured Resources

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Use Tapestri Designer to design a custom panel tailored to your needs.

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