poster

Method to analyze mutational and phenotypic profiles from single cell for clonal evolution

Saurabh Parikh

This poster demonstrates the capability of the Tapestri Platform multi-omics workflow (which analyzes the DNA and protein information from the same cells) to discriminate cell populations. Using a two-donor PBMC mixture as a model system, we show how processing on Tapestri identifies two clones using the genetic variants and multiple cell types including T-cells, B-cells, monocytes, and NK-cells using phenotypic expression. Moreover, Tapestri identified the proportion of each cell type belonging to each of the two donors.

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poster

Comprehensive On-and Off-target Confirmation Using Integrated rhAmpSeq and Targeted DNA Sequencing Single-Cell Technology

poster

Single-cell Multi-omics Analysis Reveals Differential Lineage-specific Vector Copy Number Distribution in CAR-T Cell Products

Yilong Yang; Saurabh Parikh; Khushali Patel; Qawer Ayaz; Lindsey Murphy; Amanda Winters; Terry J. Fry; Mahir Mohiuddin; Hua-Jun He; John Elliott; Benjamin Schroeder; Shu Wang; Chieh-Yuan (Alex) Li

poster

High Throughput Single-cell Assessment of Genome Integrity and Toxicity Events Associated With Edited Cells

Chieh-Yuan (Alex) Li; Saurabh Parikh; Saurabh Gulati; Donjo Ban; Nechama Kalter; Michael Rosenburg; Qawer Ayaz; Joanne Nguyen; Benjamin Miltz; Yang Li1; Madhumita Shrikhande; Edward Szekeres; Ayal Hendel; Benjamin Schroeder; Shu Wang

poster

Single-cell Multiomic Clonal Tracking in Myeloma Identifies SMM Clones that Progress to MM and Low-Frequency MM Clones with Resistance Features Enabling More Precise Application of Targeted Therapies

Adam Sciambi

Method to analyze mutational and phenotypic profiles from single cell for clonal evolution

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