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poster

Method to analyze mutational and phenotypic profiles from single cell for clonal evolution


Saurabh Parikh

This poster demonstrates the capability of the Tapestri Platform multi-omics workflow (which analyzes the DNA and protein information from the same cells) to discriminate cell populations. Using a two-donor PBMC mixture as a model system, we show how processing on Tapestri identifies two clones using the genetic variants and multiple cell types including  T-cells, B-cells, monocytes, and NK-cells using phenotypic expression. Moreover, Tapestri identified the proportion of each cell type belonging to each of the two donors.


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poster
Single-Cell Multi-Omic Correlation of Single Nucleotide Variants, Copy Number Variation, and Surface Epitopes for Clonal Profiling of Myeloma
Adam Sciambi; Indira Krishnan; Ben Geller; Daniel Mendoza; Chenchen Yang; Charlie Murphy; Cedric Dos Santos; Vivek S. Chopra; Habib Hamidi; Michael Nixon; Yann Nouet; Todd Druley; Herve Avet-Loiseau
poster
Decoding the mosaicism of genome editing with single-cell multi-omics analysis
Saurabh Gulaiti
poster
Single-Cell Multi-Omic Correlation of Single Nucleotide Variants, Copy Number Variation, and Surface Epitopes for Clonal Profiling of Myeloma
Adam Sciambi, Cedric Dos Santos, Vivek S. Chopra, Habib Hamidi, Michael Nixon, Yann Nouet, Todd Druley, Herve Avet-Loiseau
poster
A Multiomic, Single-Cell Measurable Residual Disease (scMRD) Assay For Phasing DNA Mutations and Surface Immunophenotypes
Charlie Murphy
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