Unprecedented resolution with the Tapestri Solution for Solid Tumor Research
In order to stop cancer in its tracks, before it begins, and while undergoing treatment, we need high-resolution tools capable of unmasking the underlying genetic diversity across cell populations by providing insights into the clonal architecture, mutation co-occurrence, and rare mutations driving tumor progression and therapy resistance.
Single-cell DNA sequencing using the Tapestri Platform provides the resolution required to profile thousands of individual cells or nuclei, enabling a much richer characterization of tumor heterogeneity and clonality.
Tapestri Platform Benefits
- Simultaneously measures SNVs, indels, and arm-level and gene-level copy number variations (CNVs), including loss of heterozygosity (LOH) at the single-cell level across up to 10,000 cells
- Unambiguously identifies variant zygosity and mutational co-occurrence
- Detects rare cell populations
The new end-to-end single-cell DNA sequencing workflow on the Tapestri Platform includes single-cell DNA panels for solid tumor research, nuclei isolation prep protocol, and an improved single-cell CNV analysis tool. With this new workflow, solid tumor researchers can now utilize Tapestri to elucidate the mechanisms of drug resistance through mutation acquisition, determine how cells transform from benign to malignant states, and reveal the genomic changes enabling cancer cells to metastasize.
