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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
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poster

Precise Measurement of Transduction Efficiency at Single-Cell Resolution for Cell and Gene Therapy Development


Khushali Patel

Cell and gene therapies are transformative solutions for diseases where existing interventions are ineffective. Many such therapies rely on the introduction of transgenes into host cells using viral or non-viral vectors. The accurate measurement of gene transfer is critical to the development of such therapies and is critical for assessing their safety and efficacy. Yet, conventional methods for measuring gene transfer either report a population average (bulk) or involve laborious and time-consuming clonal outgrowth which can take up to 14 days. Mission Bio has developed an end-to-end solution from panel design to data analysis for single-cell targeted DNA sequencing. Using the Tapestri platform we demonstrate that single-cell DNA sequencing identifies transduced versus non-transduced cells with exceptional accuracy and precision for populations of up to 10,000 cells while reducing sample processing time from weeks to days.


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poster
Leveraging Single-cell DNA Sequencing for In-depth Characterization of Cell and Gene Therapies
Jacqueline Marin, Benjamin Schroeder, Shu Wang, Daniel Mendoza, Adam Sciambi, Brittany Enzmann
poster
Multimodal Analysis of DNA and Proteins in Single Cells
Prithvi Singh, Dalia Dhingra, Saurabh Parikh, Adam Sciambi, Aik Ooi
poster
Enabling single cell analysis of copy number variation in breast cancer
Jacqueline Marin
poster
Linking phenotype and genotype: multimodal analysis of surface proteins, intracellular proteins, and SNVs in single cells
Aik Ooi
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