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Precise Measurement of Transduction Efficiency at Single-Cell Resolution for Cell and Gene Therapy Development


Khushali Patel

Cell and gene therapies are transformative solutions for diseases where existing interventions are ineffective. Many such therapies rely on the introduction of transgenes into host cells using viral or non-viral vectors. The accurate measurement of gene transfer is critical to the development of such therapies and is critical for assessing their safety and efficacy. Yet, conventional methods for measuring gene transfer either report a population average (bulk) or involve laborious and time-consuming clonal outgrowth which can take up to 14 days. Mission Bio has developed an end-to-end solution from panel design to data analysis for single-cell targeted DNA sequencing. Using the Tapestri platform we demonstrate that single-cell DNA sequencing identifies transduced versus non-transduced cells with exceptional accuracy and precision for populations of up to 10,000 cells while reducing sample processing time from weeks to days.


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poster
Single-Cell Multi-Omic Correlation of Single Nucleotide Variants, Copy Number Variation, and Surface Epitopes for Clonal Profiling of Myeloma
Adam Sciambi; Indira Krishnan; Ben Geller; Daniel Mendoza; Chenchen Yang; Charlie Murphy; Cedric Dos Santos; Vivek S. Chopra; Habib Hamidi; Michael Nixon; Yann Nouet; Todd Druley; Herve Avet-Loiseau
poster
Decoding the mosaicism of genome editing with single-cell multi-omics analysis
Saurabh Gulaiti
poster
Single-Cell Multi-Omic Correlation of Single Nucleotide Variants, Copy Number Variation, and Surface Epitopes for Clonal Profiling of Myeloma
Adam Sciambi, Cedric Dos Santos, Vivek S. Chopra, Habib Hamidi, Michael Nixon, Yann Nouet, Todd Druley, Herve Avet-Loiseau
poster
A Multiomic, Single-Cell Measurable Residual Disease (scMRD) Assay For Phasing DNA Mutations and Surface Immunophenotypes
Charlie Murphy
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