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Announcing new Tapestri Platform updates including lowered input threshold and expanded heme-onc menu. Learn More
RESEARCHER spotlight
Elisa Ten Hackn, PhD
Dana Farber Cancer Institute

Detecting multiple CRISPR-edited gene modifications

Have you ever wondered what were the exact indels that were made to the DNA after genome editing experiments? Have you wondered what percentage of the cells had certain edits? Have you ever wondered whether the edits were made on only one chromosome or both chromosomes to reveal the zygosity of the edit? Using single-cell DNA sequencing on the Tapestri Platform, the Wu Lab from Dana Farber did just that. Dr. Elisa Ten Hacken shares her recent work using genome editing to create mouse models of chronic lymphocytic leukemia (CLL).

RESEARCHER spotlight
Two mutations in RNA splicing factors from the same cell confirmed with single-cell DNA-Seq
Justin Taylor, MD
University of Miami
RESEARCHER spotlight
Enhance the clinical evaluation of AML MRD by uncovering clonality
Asiri Ediriwickrema, MD
Stanford University
RESEARCHER spotlight
Using CRISPR to understand different combinations of gene alterations
John Lee, MD, PhD
Fred Hutch
RESEARCHER spotlight
Single-cell analysis reveals extensive proteogenomic decoupling in leukemia
Adam Abate, PhD; Ben Demaree; Cyrille Delley