Myeloid Clonal Evolution Published Panel

Tapestri Single-cell DNA Myeloid Clonal Evolution Published Panel was designed by the Ross Levine Lab at Memorial Sloan Kettering Cancer Center. The Myeloid Clonal Evolution Published Panel was featured in a study published in Nature, “Single-cell mutation analysis of clonal evolution in myeloid malignancies.” Researchers examined the order of mutation acquisition, impact of co-occurring mutations on clonal fitness and expansion, and correlation between co-mutations and immunophenotypic profiles across clonal hematopoiesis (CH), myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML) by sequencing 740,529 cells in 146 samples from 123 patients with myeloid malignancies.