Myeloid Published Panel

Tapestri Single-cell DNA Myeloid Published Panel was designed by the Koichi Takahashi Lab at MD Anderson Cancer Center and covers many of the recurrent gene mutations in myeloid malignancies. This panel is featured in a study published in Nature Communications, “Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics.” Researchers uncovered the landscape of AML clonal architecture, revealed clonal relationships of AML driver mutations, and reconstructed the mutational history of driver genes in 154 AML samples from 123 patients. In 26 of these patients, they simultaneously examined genotype-to-phenotype correlation at single-cell resolution. In addition, scDNA-seq of longitudinal samples in 15 patients allowed illustration of clonal evolution in response to therapeutic selective pressures.