DNA is the template for human biology and the point where a single mutation initiates disease. By taking a holistic approach, we can investigate every part of the cell and the changes that occur over time to match the appropriate therapies to patients. However, bulk sequencing only looks at averages, thereby missing mutational diversity. Using novel droplet microfluidics, it is possible to encapsulate and barcode individual cells, while preserving their mutational profile, to observe clonal changes over time. The Tapestri Platform uses a two-step workflow that maximizes DNA capture efficiency and minimizes allele dropout.