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Announcing the new Tapestri scMRD Assay for AML. Learn More
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Oncology

Tumor Heterogeneity Demands Precision Tools

Cancer is complex. Only with Mission Bio can you gain the full multiomic understanding of diseases and the therapeutics necessary to combat them.

Why Single Cell for Oncology?

The heterogeneity and dynamism of cancer present formidable challenges to treating the disease. Through an iterative process of mutation and cell expansion, tumors generate genetic and phenotypic heterogeneity, contributing to the complexity of the disease.

Advances in single-cell technology are enabling researchers to precisely reconstruct tumor phylogenies and reveal the clonal architecture of tumors, with profound implications for diagnosis, prognosis, and treatment of cancer.

Mission Bio’s Tapestri Platform enables highly sensitive targeted DNA sequencing at the single-cell level, measuring SNVs, indels, chromosomal rearrangements and CNVs, as well as structural characteristics like zygosity, mutational co-occurrence, and the presence of rare cell populations. Moreover, Tapestri enables simultaneous measurement of genotype and immunophenotype across thousands of cells in a single assay to allow a thorough depiction of the tumor’s clonal diversity.

Single-cell applications in oncology

Clonal evolution
Track clonal evolution and reconstruct phylogenetic trees
Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics
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Tumor Profiling
Unravel tumor heterogeneity and discern early driver gene alterations
Single-cell DNA analysis with nuclei isolated from solid tumor tissue
VIEW APP NOTE
Disease Modeling
Assess genome editing for use in pre-clinical disease modeling
Single-cell DNA analysis of a novel acute erythroid leukemia (AEL) CRISPR induced mouse model
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Therapeutic Resistance
Reveal therapy resistance mechanisms through course of treatment
Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib
VIEW PAPER
Minimal Residual Disease (MRD)
Monitor disease during remission
to track MRD
Single-cell mutational profiling enhances the clinical evaluation of AML MRD
VIEW PAPER
Clonal Hematopoiesis of Indeterminate Potential (CHIP)
Distinguish leukemic clones from age-related clonal hematopoiesis
Personalized single-cell proteogenomics to distinguish acute myeloid leukemia from nonmalignant clonal hematopoiesis
VIEW PAPER

Areas of Interest

Hematologic Malignancies
Gain comprehensive insights into disease progression, development of resistance, and MRD
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Solid Tumors
Uncover tumor heterogeneity that drives cancer evolution and treatment response
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PEER SCIENCE
PRODUCTS

The Tapestri Platform

The first and only single-cell technology developed to reveal biomarkers that help stratify patients, signal resistance, and predict relapse. Tapestri’s powerful multi-omics capability — connecting genotype and phenotype — opens the door to a deeper understanding and improved treatment of cancer.
Tapestri product image with an instrument, reagent kit and analysis software displaying a fish plot
Tapestri Platform
An end-to-end workflow from sample preparation to visualization with publication-ready insights for single-cell analysis.
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Panels
Targeted panels provide focus on key regions of interest for efficient use of sequencing budget and analysis time.
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Pharma Assay Development (PAD)
Custom, end-to-end, single-cell multi-omics service offerings and advanced therapeutic development.
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Featured Resources

ALL RESOURCES

Ready to learn more?

Use Tapestri Designer to design a custom panel tailored to your needs.

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