technical note

Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia (AEL) CRISPR Induced Mouse Model

Acute erythroid leukemia (AEL) is a high-risk form of acute myeloid leukemia, but models of this rare disease are lacking. In this application note, CRISPR and single-cell DNA sequencing are used to generate and analyze mouse models of AEL. Single-cell analysis of serially transplanted tumors revealed the clonal structure and co-mutations responsible for tumorigenesis.

The following are covered:

Assessment of precise genetic edits
Analysis of the clonal structure & co-mutations of AEL
Use of CRISPR and scDNA-seq for disease modeling

technical note

Assessment of Whole-Genome Copy Number Variation with Tapestri Single-Cell Analysis

technical note

Beyond basic characterization: the synergistic power of Tapestri and patient-derived xenografts to accelerate drug discovery

technical note

High-throughput assessment of genome edited cells with Tapestri antibody hashing

technical note

Unprecedented Resolution of Genome Editing Outcomes with Single-cell Analysis

Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia (AEL) CRISPR Induced Mouse Model

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