Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
X
Announcing new Tapestri Platform updates including lowered input threshold and expanded heme-onc menu. Learn More
X
publication

Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing


Lim, K. et al.
Blood Advances (2021)
Abstract

Advanced systemic mastocytosis (advSM) is a clonal stem cell neoplasm that includes aggressive SM (ASM), SM with an associated hematologic neoplasm (AHN), and mast cell leukemia. The median survival is 41 months for ASM, 24 months for SM-AHN, and <6 to 18 months for mast cell leukemia. KIT D816V mutation can be detected in >90% of SM patients.  Interestingly, multilineage involvement of KIT D816V and multimutations in other genes such as SRSF2ASXL1, and RUNX1 are frequently detected in advSM.  Some of the above-mentioned mutations were found to precede the KIT D816V mutation, indicating that the KIT mutation is a phenotypic mutation in SM. The presence and number of several mutated genes such as the SRSF2ASXL1RUNX1 panel are associated with worse prognosis in advSM.



Authors

Lim, K., Wu, J., Huang, T., Jhuang, J., Chang, Y., Lin, H., Chiang, Y., Su, Y., Chen, C.G., Chang, Y., Lin, J.



VIEW

publication
Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes
Sahoo S.S.
Nature Medicine (2021)
publication
Evolutionary predictability of genetic versus nongenetic resistance to anticancer drugs in melanoma
Marin-Bejar, O.
Cancer Cell (2021)
publication
Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias
Thijssen, R.
Blood (2021)
publication
Personalized single-cell proteogenomics to distinguish acute myeloid leukemia from nonmalignant clonal hematopoiesis
Dillon, L.W.
Blood Cancer Discovery (2021)
REQUEST QUOTE