Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
X
Announcing the new Tapestri scMRD Assay for AML. Learn More
X
publication

Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing


Lim, K. et al.
Blood Advances (2021)
Abstract

Advanced systemic mastocytosis (advSM) is a clonal stem cell neoplasm that includes aggressive SM (ASM), SM with an associated hematologic neoplasm (AHN), and mast cell leukemia. The median survival is 41 months for ASM, 24 months for SM-AHN, and <6 to 18 months for mast cell leukemia. KIT D816V mutation can be detected in >90% of SM patients.  Interestingly, multilineage involvement of KIT D816V and multimutations in other genes such as SRSF2ASXL1, and RUNX1 are frequently detected in advSM.  Some of the above-mentioned mutations were found to precede the KIT D816V mutation, indicating that the KIT mutation is a phenotypic mutation in SM. The presence and number of several mutated genes such as the SRSF2ASXL1RUNX1 panel are associated with worse prognosis in advSM.



Authors

Lim, K., Wu, J., Huang, T., Jhuang, J., Chang, Y., Lin, H., Chiang, Y., Su, Y., Chen, C.G., Chang, Y., Lin, J.



VIEW

publication
Phenotypic signatures of immune selection in HIV-1 reservoir cells
Weiwei Sun
Nature
publication
Mutated cells mediate distinct inflammatory responses in clonal hematopoiesis
J. Brett Heimlich
BioRxiv
publication
scTAM-seq enables targeted high-confidence analysis of DNA methylation in single cells
Bianchi A
Genome Biology (2022)
publication
Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia
Troy T. Robinson
BioRxiv (2022)
REQUEST QUOTE