The complexity of cancer is vast, and it is critical to measure the network of biological interactions accurately and minimize inferences. With Mission Bio’s hematology panels, you can simultaneously analyze DNA mutations and protein expression, to discover clonal networks otherwise obfuscated by bulk methods done in parallel. By connecting genotype to phenotype at the single-cell level, you can gain comprehensive insights into disease progression, development of resistance, and minimal residual disease (MRD).
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LEARN MOREFor hematologic malignancies, simultaneous DNA and protein analysis from the same cell can resolve the zygosity of mutations, determine if mutations co-occur or are mutually exclusive, and correlate that to immunophenotypes. With these insights, phylogenetic trees can be reconstructed to determine the order of acquisition of these mutations. Fish plots show how clonal architecture changes throughout the course of treatment. And monitoring during remission poses great promise for sensitive MRD detection.
It is time to get a holistic view of cancer
Order predesigned hematology panels or customize any panel with your own targets
Select panel content relevant to your specific sequencing applications to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several catalog targeted panels based on public databases and actionable clinical targets.
Katherine D. Cummins, MD, FRACP, FRCPA, University of Pennsylvania
WATCH VIDEOProviding cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.
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