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Genome Editing.

Because zygosity and co-occurrence of multiple on and off-edit targets make a difference

Genome editing libraries are powerful tools to advance our understanding and treatment of complex diseases. With single-cell analysis, you can perform CRISPR validation and gain a holistic view of the sample with data integrated across mulitple dimensions. Removing inferences, you can find answers to co-occurrence of on- and off-target edits, zygosity, transduction, and translocations with single-cell data. Characterize the workings of genome editing experiments in unprecedented detail.

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Why Single Cell for Genome Editing Applications?

Genome editing experiments require tools for proper quality control. Single-cell DNA-seq data determines whether on- and off-target edits are being made in the same single cells and reveal every combination of edits at multiple sites, directly from the DNA. These data can be acquired for both human or mouse model experiments, with custom panels easily designed using Tapestri Designer that covers the entire human and mouse genome, making it perfectly suited for CRISPR validation.

It is time to unlock biological complexity

Combine genome editing with mouse models to study solid tumors
Combine genome editing with mouse models to study solid tumors
Tapestri Platform resolves clonality of heterogeneous mouse organoid cancer model through single-cell DNA sequencing of lentiviral barcodes
Dr. John Lee, Fred Hutch
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Measure multiple on- and off-target genome editing events
Measure multiple on- and off-target genome editing events
Measuring the efficiency of CRISPR genome-editing systems using the Tapestri Platform and Tapestri Single-cell DNA custom panel
Pharma Company
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Design your own custom panel with Tapestri Designer
Design your own custom panel with Tapestri Designer
Customize your content to your research
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Custom DNA Panels with Tapestri Designer

Customize your content to your research

Create unique single-cell DNA panels to fit your research needs and reveal the true clonal heterogeneity in your samples. Use custom panels to study DNA changes in human cells or mouse models of disease. Run CRISPR validation and quantify on- and off-target events anywhere in the entire genome.

DESIGN YOUR CUSTOM DNA PANEL WITH TAPESTRI DESIGNER

Discover how single-cell DNA sequencing using lentiviral barcodes resolves the clonality of genome-edited mouse organoids in a bladder cancer model.

John K. Lee, M.D., Ph.D., Fred Hutchinson Cancer Center

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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Hematology
Clonal evolution impacts response, resistance, relapse, and residual disease.
Solid Tumor
Profiling enables high resolution of the genomic diversity in a variety of tumor types.

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Use Tapestri Designer to design a custom panel tailored to your needs.

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