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Genome Editing

Because the order of mutational acquisition and MRD detection make a difference.

Genome editing libraries are powerful tools to induce several mutations in human and mouse models of disease and enable the study of complex multi-mutational landscapes underlying cancer as well as numerous other diseases. Using single-cell DNA-seq, investigators can perform quality control on their genome-editing experiments and determine whether on- and off-target edits at multiple alleles have occurred in the same single cells.

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Why Single Cell for Genome Editing Applications?

Genome editing requires tools for quality control to determine whether on- and off-target edits are being made in the same single cells. Single-cell DNA-seq data reveals all these combinations at multiple sites, directly from the DNA. These data can be acquired for both human cell line experiments or mouse model experiments. And, custom panels are easily designed using Tapestri Designer, which covers the entire human and mouse genome.

See how single-cell DNA sequencing applications provide a unique tool to interrogate at mouse models and genome editing experiments

Combine genome editing with mouse models to study solid tumors
Combine genome editing with mouse models to study solid tumors
Tapestri Platform resolves clonality of heterogeneous mouse organoid cancer model through single-cell DNA sequencing of lentiviral barcodes
Dr. John Lee , Fred Hutch
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Measure multiple on- and off-target genome editing events
Measure multiple on- and off-target genome editing events
Measuring the efficiency of CRISPR genome-editing systems using the Tapestri Platform and Tapestri Single-cell DNA custom panel
Pharma Company
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Design your own custom panel with Tapestri Designer
Design your own custom panel with Tapestri Designer
Customize your content to your research
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Custom Panels with Tapestri Designer

Kick off your single-cell research with a pre-designed panel in hematology or design your own using Tapestri Designer

Select panel content relevant to your specific indication to understand the nature of the disease and potential mechanisms of therapeutic resistance. We offer several pre-designed targeted panels for hematologic cancers based on actionable clinical targets. Order the pre-designed panels as is, or easily add or subtract content to customize your research using Tapestri Designer.

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CAPABILITIES

DNA Is Our Foundation

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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SNV + CNV
Characterize genomic heterogeneity using a single, comprehensive platform.
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Single-cell Multi-omics (DNA+)
DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Other APPLICATIONS
Hematology
Clonal evolution impacts response, resistance, relapse, and residual disease.
Solid Tumor
Profiling enables high resolution of the genomic diversity in a variety of tumor types.

Featured Resources

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Use Tapestri Designer to design a custom panel tailored to your needs.

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