DNA-Protein | Mission Bio

DNA-Protein

One Cell. Genotype + Phenotype.

Because the complexity of cancer needs both.

The Tapestri Platform is the first and only single-cell multi-omics platform capable of detecting SNVs, CNVs, and protein changes simultaneously from the same cell. Perform true multi-omics with genotype and phenotype for your critical cancer research.

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Key Benefits CASE STUDY Applications Workflow DATASETS RESOURCES

Why Single Cell for DNA and Protein?

Cancer is a complex disease with a mix of cells with varied states, and understanding of the disease state at the cellular level is required for better therapies. A single-cell multi-omics approach is the only way to achieve full resolution, revealing the complex interplay between genotype and phenotype.

Perform true multi-omics with simultaneous detection of SNVs, CNVs, and protein at the single-cell level.

Correlate immunophenotype with genotype from the same cell

Detect rare subpopulations with maximum resolution using SNVs, CNVs, and protein expression

Differentiate pre-cancerous cell populations from pre-cancerous clones without FACS pre-enrichment

Explore insights of single-cell multi-omics in myeloid malignancies.

Ross Levine, M.D., Memorial Sloan Kettering Cancer Center

Target the diversity that matters with content in a custom panel, or start with one of our pre-designed panels.

Explore Hematology

See how single-cell DNA sequencing transforms the study of hematological malignancies.

The Tapestri Workflow

Plug and play into your existing next-generation sequencing workflow with sample prep and analysis solutions using the Tapestri Platform.

Target Selection

Choose a pre-designed panel or design a
custom panel

Catalog Panels Custom Panels with Tapestri Designer

SAMPLE
PREP

Simple protocol for cell staining

LIBRARY
PREP

Single workflow
combines dna and protein panels

Tapestri Instrument

SEQUENCING

Single sequencing run for snvs, cnvs, and proteins

PIPELINE

Integrated pipeline
for multi-omics analysis

Tapestri Pipeline

ANALYSIS

powerful analysis and
visualization software

Tapestri Insights

Datasets

Explore the datasets below using single-cell multi-omics analysis.

NAME

DESCRIPTION

LAST UPDATED

4 Cell Line Mix for SNV, CNV, and Protein Multi-omics Analysis

Sample dataset for the Tapestri Single Cell DNA AML panel

12.06.2019

Featured Resources

Scientific Presentation

Investigation of AML clonal architecture with mutational and immunophenotypic profiling simultaneously from the same cell(s)
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publication

Joint profiling of proteins and DNA in single cells reveals extensive proteogenomic decoupling in leukemia
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spotlight

Immune-Based Therapies for Hematology: Single-cell Multi-omics and Cell Therapies for Leukemias
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OTHER CAPABILITIES

DNA Is Our Foundation

Providing cancer specialists with the only single-cell targeted DNA solution that integrates CNV, SNV, and protein data from the same cell.

Single-cell Genomics (DNA)

SNV

Detect rare clonal populations and identify co-occurrence and zygosity.

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SNV + CNV

Characterize genomic heterogeneity using a single, comprehensive platform.

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Ready to build your DNA + Protein panel?

Chat with one of our design experts to build a panel to simultaneously detect SNVs, CNVs, and protein expression.

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