Tapestri Platform | Mission Bio

One Platform. Genotype + Phenotype.

The Tapestri Platform is the first and only single-cell multi-omics platform that simultaneously provides both genotype and phenotype data from the same cell, across thousands of cells. With DNA as a foundation, our proprietary two-step workflow enables the detection of any analyte to meet the complexity of cancer with true multi-omics.

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The Tapestri Platform: A total solution for true multi-omics at the single-cell level

Two steps. DNA + any analyte. Endless possibilities.

Our novel two step workflow is foundational to accessing DNA, along with other changes in the cell that are crucial to studying tumor biology. Co-detection of a genotype along with protein expression from the same cell provides the ultimate solution for true multi-omics.

Targeted and customizable.

Select your target genes of interest to streamline your research budget and analysis time for biological insights. Whether you start with one of our curated pre-designed panels or Tapestri Designer for custom panels, our optimized AI design pipeline will ensure a panel with high uniformity delivered in just weeks.

Confidence in a complete solution.

With our core kits with reagents and cartridges, we take you from single cells to a sequencing-ready library. Once data is generated, our plug-and-play analysis workflows with pipeline and visualization software then take you from data to publication-ready insights.

The Complete Tapestri Workflow

Single-cell DNA and protein analysis integrates seamlessly into your existing next-generation sequencing workflow with sample prep and analysis solutions using the Tapestri Platform.

Target Selection

Choose a pre-designed panel or design a
custom panel

Catalog Panels Custom Panels with Tapestri Designer

SAMPLE
PREP

Simple protocol for cell staining

LIBRARY
PREP

Single workflow
combines dna and protein panels

Tapestri Instrument

SEQUENCING

Single sequencing run for snvs, cnvs, and proteins

PIPELINE

Integrated pipeline
for multi-omics analysis

Tapestri Pipeline

ANALYSIS

powerful analysis and
visualization software

Tapestri Insights

Library Prep with Tapestri

A unique and robust two-step microfluidics workflow

Our patented two-step workflow and proprietary multiplex chemistry unlock access to DNA and more, allowing for high-throughput multi-omics analysis of single cells. Each droplet is discretely optimized for each reaction step: isolation of DNA in the first droplet, followed by targeted PCR of the DNA in the second droplet.

STEP 1

CELL ENCAPSULATION

DNA + PROTEIN RELEASE

STEP 2

CELL BARCODING

TARGET AMPLIFICATION

Tapestri Two-Step Workflow: Microfluidics first encapsulate the cells into droplets with a cocktail of lysis reagents to access the genomic DNA. After neutralizing the lysis reagents, the second step introduces PCR amplification reagents and barcoded beads to specifically amplify the targets of interest.

Tapestri Reagents

Leverage our Tapestri Core Reagent Kits with any Tapestri Single-cell Panel

Optimized for use with any targeted panels.

Start with pre-designed panels curated using publications and databases, hematological malignancies, and solid tumor cancers

Create custom panels for human or mouse genomes using Tapestri Designer

Best-in-class AI-driven design engine based on wet-lab data specific to droplet-based multiplex PCR chemistry

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Our core chemistry is universal to any panel, any analyte, any sample type.

Compatible with any-size targeted panel up to 1,000 amplicons

Use with DNA-only panels or DNA + protein panels

Start with a suspension of single cells, or utilize our nuclei isolation protocol

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Tapestri Software

Tapestri software tools take your complex multi-analyte data to publication-ready insights for a comprehensive end-to-end workflow for single-cell multi-omics analysis.

Tapestri Pipeline

A complete software solution for single-cell DNA analysis.

From sequence import to data analysis and visualization, this turnkey software ensures you gain meaningful insights.

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Tapestri Insights

Leverage our optimized workflow to easily migrate your bioinformatics applications and pipelines, set up projects, view results, and collaborate in a highly secured environment.

On-demand access to compute infrastructure for immediate data processing.

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Capabilities

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

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Applications

Conduct high-throughput single-cell DNA sequencing from thousands of cells in hematology, solid tumor, and genome editing applications.

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