Tapestri Single-cell Sequencing Platform

Untangle the Complexity of Cancer with True Multi-omics.

Gain the true single-cell picture to enable precise understanding

The Tapestri Platform is the only system capable of simultaneously providing both genotype and phenotype data from the same cell, across thousands of single cells. With DNA as a foundation, our proprietary two-step microfluidic workflow enables the simultaneous detection of analytes, including SNVs, CNVs, and proteins. Meet the complexity of cancer with true multi-omics analysis.

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Tapestri product image with an instrument, reagent kit and analysis software displaying a fish plot

The Tapestri Platform: Unravel cancer’s complexity with true single-cell multi-omics

Two steps. DNA + any analyte. Endless possibilities.

Our novel two-step microfluidic workflow is foundational to access DNA and protein in single cells, providing a true multi-omics picture. Combining two assays in a single integrated workflow saves costs and time, accelerating research and drug development pipelines.

Targeted and customizable.

Leverage curated pre-designed panels of DNA and surface protein targets, or create custom panels to suit your needs. Our optimized AI design pipeline will ensure a panel with high uniformity delivered in just weeks.

Confidence in a comprehensive end-to-end workflow.

With core reagent and cartridge kits to take you from single cells to a sequencing-ready library, leverage optimized analysis tools to convert your complex multi-dimensional, multi-analyte data to actionable insights.

The Complete Tapestri Workflow

Integrate seamlessly into your existing NGS workflow with sample prep and analysis solutions using the Tapestri single-cell sequencing platform

With our single-cell sequencing platform, use the Tapestri Instrument, reagents, and consumables up-front of your NGS system and then Tapestri Pipeline and Tapestri Insights software for data analysis and visualization.

Target Selection

Choose a pre-designed or custom DNA panel

Pre-designed DNA Panels Custom DNA Panels with Tapestri Designer

SAMPLE
PREP

Add a protein panel and simple cell staining protocol

Protein Panels

LIBRARY
PREP

Single workflow combines DNA and protein panels

Tapestri Instrument

SEQUENCING

Single sequencing run for multi-omics single-cell data

PIPELINE

Integrated pipeline for multi-omics analysis

Tapestri Pipeline

ANALYSIS

Powerful analysis and visualization software

Tapestri Insights

Library Prep with Tapestri

Access high-quality data with a unique two-step microfluidic workflow

Based on a novel two-step microfluidic workflow, the Tapestri Platform can access DNA and protein in single cells to give you true multi-omics. Each reaction in the two-step workflow is discretely optimized: isolation of DNA from the cell and oligo-conjugate antibodies in the first step, followed by targeted multiplex PCR in the second step.

STEP 1

CELL ENCAPSULATION

DNA + PROTEIN RELEASE

STEP 2

CELL BARCODING

TARGET AMPLIFICATION

Tapestri Reagents

Leverage Tapestri Core Reagent Kits with Targeted DNA and Protein Panels

Targeted DNA single-cell panels

Select from pre-designed panels carefully curated for a range of cancers

Create a custom panel for utmost flexibility (human, mouse, or any other genome)

Use our best-in-class AI-driven design engine optimized for droplet-based multiplex PCR chemistry

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Targeted protein single-cell panels

Integrate oligo-tagged protein antibodies into the Tapestri workflow

Explore the optimized and fully validated TotalSeq™-D Heme Oncology Cocktail from BioLegend

Obtain concurrent measurements of DNA and proteins to uncover genotypes and phenotypes from the same cells

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Tapestri single-cell multi-omics reagent kit image

Reagent kits for DNA-only or multi-omics experiments

Use with pre-titrated protein panels or custom TotalSeq-D antibodies from BioLegend

Start with a suspension of single cells, or utilize our nuclei isolation protocol

Compatible with any size targeted DNA panel up to 1,000 amplicons

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Tapestri Software

Spend less time integrating data and more time gaining insights

Tapestri Pipeline

Use our streamlined bioinformatics workflow optimized for single-cell DNA and protein analysis

Perform automated secondary analysis

Obtain cell barcode deconvolution, read alignment, DNA variant calling, and protein expression counts

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Tapestri Insights

Leverage our user-friendly and turnkey analysis solutions for meaningful insights to advance your research

Perform tertiary analysis with powerful analysis and visualization tools

Create UMAP plots, XY plots, violin plots, bar plots, and fish plots to uncover actionable ground-truth insights

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See why multi-omics insights at the single-cell level is pivotal in understanding the complexities of the cancer ecosystem.

Jerry Radich, MD, Fred Hutchinson Cancer Center

Capabilities

Providing cancer researchers with the only single-cell multi-omics solution that simultaneously detects SNV, CNV, and protein data from the same cell.

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Applications

Conduct high-throughput single-cell DNA sequencing from thousands of cells in hematology, solid tumor, and cell and gene therapy applications.

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Ready to get started?

Use Tapestri Designer to customize a catalog panel or start from scratch with content specific to your single-cell sequencing application.

DESIGN NOW

Untangle the Complexity of Cancer with True Multi-omics.

The Tapestri Platform: Unravel cancer’s complexity with true single-cell multi-omics

The Complete Tapestri Workflow

Library Prep with Tapestri

Tapestri Reagents

Tapestri Software

See why multi-omics insights at the single-cell level is pivotal in understanding the complexities of the cancer ecosystem.

Featured Resources

Ready to get started?