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SNV-CNV

One Cell. SNVs + CNVs.

Because a change in our blueprint is where cancer begins.

The Tapestri Platform is the only single-cell targeted DNA solution that provides both single nucleotide variants (SNVs) and copy number variants (CNVs) from the same cell. Characterize genomic heterogeneity using a single platform, with comprehensive single-cell DNA analysis to co-detect all the changes in our blueprint that matter.

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Why Single Cell for SNVs and CNVs?

When determining the clonal heterogeneity across a cancer sample, it’s important to comprehensively measure both DNA mutations and copy number variants in every cell to give us higher resolution to explore tumor evolution and heterogeneity.

Gain unprecedented insight into the diversity of genomic changes with simultaneous SNV and CNV analysis from the same cell.

Obtain quality for your research with best-in-class single-cell DNA accessibility using the Tapestri two-step workflow
Use a single workflow for co-detection of gene-level to chromosome-level CNVs, LOH, and SNVs at the single-cell level
Start from cells or nuclei with maximum sample flexibility for CNV analysis

Discover how single-cell SNV and CNV analysis helps better resolve the heterogeneity in renal cell carcinoma (RCC) samples.

Samra Turajlic, M.D., Francis Crick Institute

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Design Your Panel
Target the diversity that matters with SNV and CNV content in a custom panel.
Explore Hematology
See how single-cell DNA sequencing transforms the study of hematological malignancies.

The Tapestri Workflow

Plug and play into your existing next-generation sequencing workflow with sample prep and analysis solutions using the Tapestri Platform.

Target Selection
Choose a pre-designed panel or design a
custom panel
SAMPLE
PREP
Simple protocol for cell staining
LIBRARY
PREP
Single workflow
combines dna and protein panels
SEQUENCING
Single sequencing run for snvs, cnvs, and proteins
PIPELINE
Integrated pipeline
for multi-omics analysis
ANALYSIS
powerful analysis and
visualization software

Datasets

Explore the datasets below using single-cell SNV and CNV analysis.

NAME
DESCRIPTION
LAST UPDATED

Sample dataset for a 4-cell line mixed experiment using the Tapestri Single-Cell DNA AML_v2 panel

09.30.2019

Sample dataset for a KG-1:Raji cell lines 50:50 mix experiment using the Tapestri Single-Cell DNA Myeloid panel

09.30.2019

Featured Resources

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DNA Is Our Foundation

Providing cancer specialists with the only single-cell targeted DNA solution that integrates CNV, SNV, and protein data from the same cell.

Single-cell Genomics (DNA)
SNV
Detect rare clonal populations and identify co-occurrence and zygosity.
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Single-cell Multi-omics (DNA+)
DNA + RNA
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DNA + Protein
Gain a true multi-omics picture from genotype to phenotype.
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Ready to build your SNV + CNV panel?

Chat with one of our design experts to build a panel to simultaneously detect SNVs and CNVs.

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