Polyclonal heterogeneity: the new norm for secondary clinical resistance to targeted monotherapy in relapsed leukemia?
Wei, A. et. al., Cancer Discovery (2019)
Clonal evolution and changes in two AML patients detected with a novel single-cell DNA sequencing platform
Xu, L. et. al., Scientific Reports (2019)
V211D mutation in MEK1 causes resistance to MEK inhibitors in colon cancer
Gao, Y. et. al., Cancer Discovery (2019)
Clonal selection with Ras pathway activation mediates secondary clinical resistance to selective FLT3 inhibition in acute myeloid leukemia
McMahon, C. et. al., Cancer Discovery (2019)
High-throughput single-cell DNA sequencing of acute myeloid leukemia tumors with droplet microfluidics
Eastburn, D. et. al., Genome Research (2018)
Differential roles for Lgr5 and Lgr6 in epidermal stem cell lineage selection and squamous tumour development.
Huang, P., et. al., Nature Genetics (2017)
RNA-Seq following PCR-based sorting reveals rare cell transcriptional signatures.
Pellegrino, M., et. al., BMC Genomics (2016)
Microfluidic droplet enrichment for targeted sequencing.
Eastburn, D. et. al., Nucleic Acids Research (2015)
In pursuit of the leukemic stem cell: leveraging single cell genomics and proteomics to identify drivers of AML
Investigation of AML clonal architecture with mutational and immunophenotypic profiling simultaneously from the same cell(s)
High-throughput Single Cell DNA Sequencing of Acute Myeloid Leukemia Tumors by Droplet Microfluidics
Precision Sequencing with Single-Cell Genomics: Resolving Heterogeneity in Blood and Solid Tumors
Katherine D. Cummins, MD, FRACP, FRCPA
Single-cell Multiomics and Cell Therapies for Leukemia (Video)
Ravi Majeti, MD, PhD
Transforming the detection of minimal residual disease (MRD) with single-cell DNA analysis (pdf)
Data should be loaded in the Tapestri Insights software for cell and variant filtering and subclone analysis.