The ability to predict the future behaviour of an individual cancer is crucial for precision cancer medicine and, in particular, for the development of strategies that prevent acquisition of resistance to anti-cancer drugs. Therapy resistance, which often develops from a heterogeneous pool of drug-tolerant cells known as minimal residual disease (MRD), is thought to mainly occur through acquisition of genetic alterations. Increasing evidence, however, indicates that drug resistance might also be acquired though nongenetic mechanisms. A key emerging question is therefore whether specific molecular and/or cellular features of the MRD ecosystem determine which of these two distinct resistance trajectories will eventually prevail.
Marin-Bejar, O., Rogiers, A., Dewaele, M., Femel, J., Karras, P., Pozniak, J., Bervoets, G., Raemdonck, N.V., Pedri, D., Swings, T., Demeulemeester, J., Borght, S.V., Bosisio, F., van den Oord, J.J., Bempt, I.V., Lambrechts, D., Voet, T., Bechter, O., Rizos, H., Levesque, M., Leucci, E., Lund, A.W., Rambow, F., Marine, J.C.