Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib
Peretz CAC, McGary LHF, Kumar T, Jackson H, Jacob J, Durruthy-Durruthy R, Levis MJ, Perl A, Huang BJ, Smith CC
Blood Advances
Mar 2021
Abstract
Single-cell sequencing exposes previously unmeasurable complexity of tumor heterogeneity and clonal evolution on quizartinib. Single-cell sequencing reveals on- and off-target mechanisms of resistance to quizartinib, which can preexist therapy.
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Area
Heme
Institution Type
Academia
Indication / Modality
Acute Myleoid Leukemia (AML)
Goal of Study
Therapeutic Resistance, Clonal Evolution, Longitudinal, Clonal Heterogeneity
Key Genes
FLT3, RAS, KIT
PAD Project
No
Analytes Assessed
SNV, InDels
Sample Storage
Fresh Frozen
Sample Prep
Whole Cells
Sample Type
Patient Material, PBMC
Tissue / Organ
Bone Marrow Aspirates
Species
Human
Panel Used
Custom
Proof Point Demonstrated
Co-occurrence, Clonality, Better than Bulk
