publication

A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN

Xiao, W. et al.
Blood Advances (2020)

Abstract

Myeloid neoplasm (MPN) clones can evolve from acute myeloid leukemia to gain dominance with isocitrate dehydrogenase inhibition.
Pro-differentiation agents such as ivosidenib can unmask MPN sequelae.

Authors

Xiao, W., Miles, L.A.., Bowman R.L., Durani, V., Tian H.S., DelGaudio, N.L., Mishra, T., Zhu, M. Zhang, Y., Stump, S.E.., Tallman, M.S., Levine, R.L.., Cai, S.F.

VIEW

publication

Gain-of-function mutations in RPA1 cause a syndrome with short telomeres and somatic genetic rescue

Sharma R

Blood (2021)

publication

Diverse alterations associated with resistance to KRAS(G12C) inhibition

Zhao Y

Nature (2021)

publication

Clinical evolution, genetic landscape and trajectories of clonal hematopoiesis in SAMD9/SAMD9L syndromes

Sahoo S.S.