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publication

A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN

Xiao, W. et al.
Blood Advances (2020)

Abstract

Myeloid neoplasm (MPN) clones can evolve from acute myeloid leukemia to gain dominance with isocitrate dehydrogenase inhibition.
Pro-differentiation agents such as ivosidenib can unmask MPN sequelae.

Authors

Xiao, W., Miles, L.A.., Bowman R.L., Durani, V., Tian H.S., DelGaudio, N.L., Mishra, T., Zhu, M. Zhang, Y., Stump, S.E.., Tallman, M.S., Levine, R.L.., Cai, S.F.

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Single cell genotypic and phenotypic analysis of measurable residual disease in acute myeloid leukemia

Troy T. Robinson

The genomic landscape of pediatric acute lymphoblastic leukemia

Samuel W. Brady

Nature Genetics

Detection of early seeding of Richter transformation in chronic lymphocytic leukemia

Nature Medicine (2022)

Modeling clonal evolution and oncogenic dependency in vivo in the context of hematopoietic transformation