A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN.
Xiao, Wenbin et al.
Blood Advances (2020)
Myeloid neoplasm (MPN) clones can evolve from acute myeloid leukemia to gain dominance with isocitrate dehydrogenase inhibition.
Pro-differentiation agents such as ivosidenib can unmask MPN sequelae.
Xiao, Wenbin, Miles, Linde A., Bowman, Robert L, Durani, Vidushi, Tian Helen S., DelGaudio, Nicole L, Mishra, Tanmay, Zhu, Menglei, Zhang, Yanming, Stump, Sarah E., Tallman, Martin S, Levine, Ross L., Cai, Sheng F.