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A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN

Xiao, W. et al.
Blood Advances (2020)

Abstract

Myeloid neoplasm (MPN) clones can evolve from acute myeloid leukemia to gain dominance with isocitrate dehydrogenase inhibition.
Pro-differentiation agents such as ivosidenib can unmask MPN sequelae.

Authors

Xiao, W., Miles, L.A.., Bowman R.L., Durani, V., Tian H.S., DelGaudio, N.L., Mishra, T., Zhu, M. Zhang, Y., Stump, S.E.., Tallman, M.S., Levine, R.L.., Cai, S.F.

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