publication

A JAK2/IDH1-mutant MPN clone unmasked by ivosidenib in an AML patient without antecedent MPN.

Wenbin, X. et al.
Blood Advances (2020)

Abstract

Myeloid neoplasm (MPN) clones can evolve from acute myeloid leukemia to gain dominance with isocitrate dehydrogenase inhibition.
Pro-differentiation agents such as ivosidenib can unmask MPN sequelae.

Authors

Wenbin, X., Miles, L.A.., Bowman R.L., Durani, V., Tian H.S., DelGaudio, N.L., Mishra, T., Zhu, M. Zhang, Y., Stump, S.E.., Tallman, M.S., Levine, R.L.., Cai, S.F.

VIEW

publication

Clonal evolution and heterogeneity in advanced systemic mastocytosis revealed by single-cell DNA sequencing

Lim, K.

Blood Advances

publication

Joint profiling of DNA and proteins in single cells to dissect genotype-phenotype associations in leukemia

Demaree, B.

Nature Communications

publication

Single-cell DNA sequencing reveals complex mechanisms of resistance to quizartinib

Peretz, C.A.C