Unprecedented Resolution of Genome Editing Outcomes with Single-cell Analysis

Mission Bio’s Tapestri® Genome Editing Solution offers a comprehensive solution for high-throughput analysis of genomic edits at single-cell resolution. Here, we showcase the robust performance of the pipeline for both insertions/deletions (indels) and single nucleotide variants (SNVs), providing precise data for on- and off-target edit frequencies, edit zygosity, and co-occurrence. We highlight the sensitivity, specificity, accuracy, and reproducibility of the sample-to-answer assay and demonstrate the versatility of our multi-omics assay, which concurrently measures cell-surface proteins and genome edits. This innovative solution is a transformative tool that equips researchers to unravel the intricacies of genome editing outcomes, fostering advancements across diverse life science applications.