Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
CLOSE
X
HOME CAPABILITIES Why Single Cell SNV SNV + CNV DNA + Protein Applications Oncology Research Multiple Myeloma AML MRD Precision Medicine Genome Editing Genome Integrity Assay Biomarker Development Cell and Gene Therapy Products & Services Tapestri Platform Panels Pharma Assay Development PAD for Cell & Gene Therapy PAD for Drug Development
RESOURCES BLOG PODCAST COMPANY About Us Careers Newsroom Events Distributors & Service Providers SUPPORT CENTER CONTACT PORTAL
X
Home Resources Presentations Longitudinal analysis reveals pre-existing resistant clones
FILTER RESOURCES
ALL FEATURED PUBLICATIONS SCIENTIFIC PRESENTATIONS RESEARCHER SPOTLIGHTS VIDEOS BROCHURES DATASETS USER GUIDES TECHNICAL NOTES POSTERS EBOOKS
Scientific presentation

Longitudinal analysis reveals pre-existing resistant clones


Catherine Smith, MD
Description

Dr. Cathy Smith from UCSF provides a case study on single-cell sequencing of polyclonal resistance to FLT3 inhibitors in acute myeloid leukemia (AML). She presents data taken over a period of 28, 48, and 92 days to reveal that NRAS clones were detectable in 0.1% of cells with single-cell analysis at 28 days, which was previously undetectable with bulk sequencing until relapse.



VIEW


Scientific presentation
Leverage Single-cell Multi-parametric Datasets to Advance Heme Oncology Pipelines
Azad Gucwa, PhD
14th World Clinical Biomarkers & Companion Diagnostics Summit (2024)
Scientific presentation
DKFZ Seminar: Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan
Martina Braun
(2024)
Scientific presentation
DKFZ Seminar: Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seq
Dominik Lindenhofer
(2024)
Scientific presentation
DKFZ Seminar: Clonal evolution in NPM1c AML
Wout Megchelenbrink
(2024)
SIGN UP FOR PRODUCT AND EVENT UPDATES
Thank you! Your submission has been received!
Oops! Something went wrong while submitting the form.
CAPABILITIES
Why Single Cell SNV SNV + CNV DNA + Protein
APPLICATIONS
Oncology Research Multiple Myeloma AML MRD Precision Medicine Genome Editing Biomarker Development Cell and Gene Therapy
PRODUCTS & SERVICES
Tapestri Platform Panels Pharma Assay Development PAD for Cell & Gene Therapy PAD for Drug Development
COMPANY CAREERS NEWSROOM EVENTS BLOG RESOURCES SUPPORT CENTER CONTACT Terms of Use Privacy Policy Terms and Conditions of Sale Client Data Security & Retention
REQUEST QUOTE