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Webinar: A New Single-Cell Sequencing and Analysis Platform to Accelerate Cell and Gene Therapy Pipelines

xTalks Webinar
June 3, 2021

Cell and gene therapies (CGTs) hold promise for the treatment of a variety of diseases including cancer and rare genetic disorders such as sickle-cell disease. Many of these therapies involve the genetic engineering of cells in order to insert exogenous sequences or alter existing genes. After the cells are altered, they are introduced into the patient where they either replace dysfunctional cells or provide a desired immune response. The use of engineered cells for human therapies requires sensitive and robust characterization of genomic manipulations, which are typically achieved through viral transduction or the use of gene editors, such as CRISPR.

All methods of genetic engineering yield cell populations with genetic heterogeneity. For instance, there may be cell-to-cell variability in transduction efficiency and copy number (for viruses), or for on- and off-target editing efficiencies (for gene editors). Because unintended genomic alterations may have consequences to the efficacy and safety of therapeutic agents, it is imperative that engineered cells be characterized with a high degree of accuracy and sensitivity. Measuring genomic manipulations at a single-cell level provides the most robust characterization of CGT products.

Register for this webinar to hear Shu Wang, Ph.D., and Matthew Cato from Mission Bio will discuss how highly sensitive single-cell DNA sequencing (scDNA-seq) on the Tapestri Platform accelerates CGT workflows. They will discuss the advantages of Tapestri for the quantification of cell-specific alterations achieved through viral vectors and gene editors, and contrast this approach to conventional multi-assay processes. They will also explain how integrating Tapestri into the CGT pipeline —from development to manufacturing and release testing — consolidates workflows and accelerates bringing breakthrough therapies to market. Lastly, Shu and Matthew will discuss how Mission Bio’s Pharma Assay Development (PAD) service enables biopharmaceutical companies to seamlessly evaluate and integrate single-cell technology into their current CGT programs.


In this webinar, participants will learn about:

  • The integration of single-cell analysis into CGT development and production workflows
  • The measurement of genomic alterations from thousands of single cells without the need for lengthy cell outgrowth protocols
  • How more parameters are measured from a single assay than in conventional methods of CGT analysis
  • How Mission Bio’s Pharma Assay Development (PAD) accelerates the time to market of CGTs


Speaker bios:

Shu Wang, PhD, is a bioinformatics scientist who specializes in single-cell DNA NGS and multi-omics assay development and data analysis. She has expertise in building bioinformatics solutions for NGS platforms and providing biology insights from massive data analysis for oncology and genomics studies.

Matthew Cato is a business and market development leader who specializes in cell and gene therapies and precision medicine. With a background in immunology and biotechnology, he focuses on strategic commercial development for single-cell technology to advance cell and gene therapeutic solutions.

1:00PM Eastern Daylight Time
xTalks Webinar
Shu Wang, PhD, Associate Director, Bioinformatics; Mission Bio Matthew Cato, Director, Cell and Gene Therapy Mission Bio