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Single-Cell Genomics Applications in Oncology Therapeutic Development: Resolving the Complexity of Cancer Heterogeneity

December 14, 2020

In oncology therapeutic development and clinical intervention, partial responses and relapse are common phenomena and a significant impediment to effective treatments for patients. As our understanding of the complex biology of cancers continues to increase, we know that a significant contributor to these effects lies in cancers harboring a diverse collection of cells with distinct and dynamic molecular profiles. This feature of cancer heterogeneity manifests in several ways: intra- and inter-tumor, intra-cellular, as well as spatial and temporal differences.

With the advent of single-cell genomic technologies, we can now interrogate cancer heterogeneity at a more fundamental level to enable more informed and potentially effective therapeutic strategies in clinical development. In this webinar, featured speakers will discuss a specific platform capable of detecting genomic content from individual cells, thereby providing insights into cancer heterogeneity and response to specific therapeutics.

In this webinar, you will learn about:

  • The multi-faceted nature of cancer heterogeneity and its impact on cancer progression & persistence
  • A single-cell analysis platform to detect and quantify genomic alterations 
  • Applications in monitoring of minimum residual disease, mutation co-occurrence and clonal evolution
11:00AM Eastern Time
Steve Anderson, PhD, Chief Scientific Officer, Covance Drug Development and Bin Wu, PhD, Senior Director, Head of Translational Medicine, Agios Pharmaceuticals Inc