Challenging the dogma that mutations in RNA splicing factors do not occur in the same cell, due to their synthetic lethal interactions and/or convergent effects, Dr. Justin Taylor from the Abdel-Wahab lab at Memorial Sloan Kettering Cancer Center show that indeed they can. Using Mission Bio’s single-cell sequencing platform, they sequenced closed to 100,000 single cells, and found instances in which mutations in splicing factors co-occurred within the same cells. Come join us as Dr. Taylor explains these exciting new data from his recent Blood publication that just came out in July 2020.
