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Technical Note

Single-Cell Multi-Omics Reveals Novel Correlations Between Genomic Variants and Protein Expression in AML Patient Samples

Abstract

Genomics data alone provides only partial insights into the cell’s type, state, or function. To obtain a more complete picture and reveal the cell’s phenotypic character, a multi-omics approach is needed that expands beyond DNA profiling. Here, we demonstrate for the first time, that the Tapestri Platform enables the detection of genomic variants and protein expression simultaneously from the same cell.


Technical Note
Model organisms and patient-derived xenografts for preclinical oncology research
Technical Note
Correlations between genomic variants and protein expression in AML patient samples
Technical Note
AML subpopulations defined by SNV, CNV, and protein expression
Technical Note
Copy number variants (CNV) and single nucleotide variants (SNV) simultaneously detected in single cells
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