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Technical Note

Single-Cell Multi-Omics Reveals Novel Correlations Between Genomic Variants and Protein Expression in AML Patient Samples

Abstract

Genomics data alone provides only partial insights into the cell’s type, state, or function. To obtain a more complete picture and reveal the cell’s phenotypic character, a multi-omics approach is needed that expands beyond DNA profiling. Here, we demonstrate for the first time, that the Tapestri Platform enables the detection of genomic variants and protein expression simultaneously from the same cell.


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Model organisms and patient-derived xenografts for preclinical oncology research
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Correlations between genomic variants and protein expression in AML patient samples
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AML subpopulations defined by SNV, CNV, and protein expression
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