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Single-cell Sequencing 101: DNA & multi-omics for precision medicine


Cancer is a complex disease that continuously evolves in response to environmental pressures. The dynamism and heterogeneity of tumors have significant clinical implications. In this eBook, review how single-cell DNA sequencing and multi-omics are used to dissect clonal architecture, providing valuable insights for clinical strategies, disease modeling, and the development of cell and gene therapies.

Specifically, we cover:

  • The clonal evolution of cancer
  • Linking genotype & phenotype with multi-omics
  • Translational applications for the clinic
  • Single-cell analysis of genome engineering

Technical Note
MGI Sequencing Platforms Produce High-Quality Performance Metrics from Tapestri Single-cell Experiments
Technical Note
Single-cell DNA Analysis of a Novel Acute Erythroid Leukemia (AEL) CRISPR Induced Mouse Model
Technical Note
Single-Cell Multi-Omics Reveals Novel Correlations Between Genomic Variants and Protein Expression in AML Patient Samples
Technical Note
In-depth quantification of cell and gene therapy DNA integrations enabled with single-cell sequencing