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Analytical methods to identify tumor heterogeneity and rare subclones in single-cell DNA sequencing data from targeted panels


Manimozhi Manivannan

High-throughput single-cell DNA sequencing is essential to assess genetic variations in rare cells and better understand the role they play in the evolution of tumor progression. To address these challenges and enable the characterization of genetic diversity in cancer cell populations, we developed a novel approach to identify mutation signatures, which define subclones present in tumor populations.


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poster
Single-cell Multiomic Clonal Tracking in Myeloma Identifies SMM Clones that Progress to MM and Low-Frequency MM Clones with Resistance Features Enabling More Precise Application of Targeted Therapies
Adam Sciambi
poster
A novel single-cell measurable residual disease (scMRD) assay for simultaneous DNA mutation and surface immunophenotype profiling
Holly Tillson
poster
Single-cell multiomic clonal tracking in myeloma identifies SMM clones that progress to MM and low frequency MM clones with resistance features enabling more precise application of targeted therapies.
Adam Sciambi
poster
High Throughput Single Cell Analysis Workflow for Accurate Measurement of Genotoxicity Arising from Gene Editing Experiments
Saurabh Gulati
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