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Analytical methods to identify tumor heterogeneity and rare subclones in single-cell DNA sequencing data from targeted panels


Manimozhi Manivannan

High-throughput single-cell DNA sequencing is essential to assess genetic variations in rare cells and better understand the role they play in the evolution of tumor progression. To address these challenges and enable the characterization of genetic diversity in cancer cell populations, we developed a novel approach to identify mutation signatures, which define subclones present in tumor populations.


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Quantification of Single Cell Vector Copy Number in CAR T Cell Products Utilizing a Novel Microfluidic Technology
Benjamin Schroeder
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Precise Measurement of Viral Copy Number at Single-Cell Resolution for Cell and Gene Therapy Development
Chieh-Yuan Li
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Single-Cell Lentiviral Vector Integration Sites and Clonal Tracking Assay for Cell and Gene Therapy
Shu Wang
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Precise Measurement of Viral Copy Number at Single-Cell Resolution for Cell and Gene Therapy Development
Matthew Cato
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