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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
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poster

Subclonal identification of driver mutations and copy number variations from single-cell DNA sequencing of tumors


James Flynn, PhD

Single-cell sequencing elucidates unique insights in understanding intratumor heterogeneity and clonal evolution. Both chromosomal structural change/copy number alteration/variation (CNA/CNV) and driver gene mutation events appear somatically at the early stages of oncogenesis and are critical in cancer initiation, tumor progression, and therapy response. We have developed a high-throughput single-cell DNA analysis platform that leverages droplet microfluidics and a multiplex-PCR-based targeted DNA sequencing approach. The platform demonstrates high-sensitivity detection of SNVs and indels in the same cells and generation of high-resolution maps of clonal architecture based on mutational profiling.


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poster
Leveraging Single-cell DNA Sequencing for In-depth Characterization of Cell and Gene Therapies
Jacqueline Marin, Benjamin Schroeder, Shu Wang, Daniel Mendoza, Adam Sciambi, Brittany Enzmann
poster
Multimodal Analysis of DNA and Proteins in Single Cells
Prithvi Singh, Dalia Dhingra, Saurabh Parikh, Adam Sciambi, Aik Ooi
poster
Precise Measurement of Transduction Efficiency at Single-Cell Resolution for Cell and Gene Therapy Development
Khushali Patel
poster
Enabling single cell analysis of copy number variation in breast cancer
Jacqueline Marin
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