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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
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Linking phenotype and genotype: multimodal analysis of surface proteins, intracellular proteins, and SNVs in single cells


Aik Ooi

The inclusion of intracellular protein detection enables the measurement of pivotal proteins in cancer mechanisms, including apoptosis (BCL2 family proteins), transcription factors (GATA3), tumor suppressors (TP53), as well as phosphorylated proteins involved in cell growth signaling pathways (phosphorylated ERK, STAT3 proteins). This is the first-ever method that provides a solution to effectively link surface and intracellular protein measurement with targeted DNA analysis. With this approach, single-cell readout of genotypic and phenotypic information can be collected together, allowing concurrent analyses of cancer clonal evolution and driver protein expression.


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poster
Enabling single cell analysis of copy number variation in breast cancer
Jacqueline Marin
poster
Single-cell multi-omic analysis of SNV, CNV, and protein expression
Aik Ooi
poster
A multimodal single-cell workflow to interrogate cellular responses to cancer therapy
Dalia Dhingra
poster
Method to analyze mutational and phenotypic profiles from single cell for clonal evolution
Saurabh Parikh
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