Method to analyze mutational and phenotypic profiles from single cell for clonal evolution

This poster demonstrates the capability of the Tapestri Platform multi-omics workflow (which analyzes the DNA and protein information from the same cells) to discriminate cell populations. Using a two-donor PBMC mixture as a model system, we show how processing on Tapestri identifies two clones using the genetic variants and multiple cell types including  T-cells, B-cells, monocytes, and NK-cells using phenotypic expression. Moreover, Tapestri identified the proportion of each cell type belonging to each of the two donors.