poster

Method to analyze mutational and phenotypic profiles from single cell for clonal evolution

Saurabh Parikh

This poster demonstrates the capability of the Tapestri Platform multi-omics workflow (which analyzes the DNA and protein information from the same cells) to discriminate cell populations. Using a two-donor PBMC mixture as a model system, we show how processing on Tapestri identifies two clones using the genetic variants and multiple cell types including T-cells, B-cells, monocytes, and NK-cells using phenotypic expression. Moreover, Tapestri identified the proportion of each cell type belonging to each of the two donors.

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poster

Single-Cell MRD Assessment in AML Reveals Clonal Diversity and Genotype–Phenotype Discordance Missed by Bulk Methods

Adam Sciambi, Daniel Mendoza, Kathryn Thompson, Lan W. Beppu, Benjamin Geller, Indira Krishnan, Lubna Nousheen, Shu Wang, Charlie Murphy, Jerald P. Radich, and Todd E. Druley

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Comprehensive On-and Off-target Confirmation Using Integrated rhAmpSeq and Targeted DNA Sequencing Single-Cell Technology

Indira Krishnan, Shu Wang, Saurabh Gulati

poster

Single-cell Multi-omics Analysis Reveals Differential Lineage-specific Vector Copy Number Distribution in CAR-T Cell Products

Yilong Yang; Saurabh Parikh; Khushali Patel; Qawer Ayaz; Lindsey Murphy; Amanda Winters; Terry J. Fry; Mahir Mohiuddin; Hua-Jun He; John Elliott; Benjamin Schroeder; Shu Wang; Chieh-Yuan (Alex) Li

poster

High Throughput Single-cell Assessment of Genome Integrity and Toxicity Events Associated With Edited Cells

Chieh-Yuan (Alex) Li; Saurabh Parikh; Saurabh Gulati; Donjo Ban; Nechama Kalter; Michael Rosenburg; Qawer Ayaz; Joanne Nguyen; Benjamin Miltz; Yang Li1; Madhumita Shrikhande; Edward Szekeres; Ayal Hendel; Benjamin Schroeder; Shu Wang

Method to analyze mutational and phenotypic profiles from single cell for clonal evolution

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