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Announcing the new Tapestri scMRD Assay for AML. Learn More
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poster

Single-cell multi-omic analysis of SNV, CNV, and protein expression


Aik Ooi

Although precision medicine is making highly promising advances, researchers still face the major technical challenge of disease heterogeneity. Single-cell technologies have greatly enhanced the degree to which sample diversity can be investigated, enabling the selection of appropriate molecular targets. Applying multi-omics analysis on single cells would further improve the understanding of cell-to-cell heterogeneity by providing unique insights on cellular and genetic composition. This poster presents the process of Mission Bio’s Tapestri Platform, which enables high-throughput targeted DNA sequencing in single cells to obtain single-nucleotide variation (SNV) and copy number variation (CNV) information. A new multi-omics workflow developed to detect protein expression in addition to DNA genotype in the same cells is also presented.


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Precise Measurement of Viral Copy Number at Single-Cell Resolution for Cell and Gene Therapy Development
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Leveraging Single-cell DNA Sequencing for In-depth Characterization of Cell and Gene Therapies
Jacqueline Marin, Benjamin Schroeder, Shu Wang, Daniel Mendoza, Adam Sciambi, Brittany Enzmann
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Multimodal Analysis of DNA and Proteins in Single Cells
Prithvi Singh, Dalia Dhingra, Saurabh Parikh, Adam Sciambi, Aik Ooi
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Precise Measurement of Transduction Efficiency at Single-Cell Resolution for Cell and Gene Therapy Development
Khushali Patel
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