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poster

Using machine learning to optimize assays for single-cell targeted DNA sequencing


Nianzhen Li
SOHO (2019)

High-throughput single-cell DNA sequencing allows for the detection of rare mutations in cells and identification of sub-clones defined by co-occurrence of mutations. The big challenge with multiplex sequencing at the single-cell level is the non-uniform amplification that results in inadequate coverage of mutations of interest.


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