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Scientific presentation

Longitudinal analysis reveals pre-existing resistant clones

Catherine Smith, MD

Description

Dr. Cathy Smith from UCSF provides a case study on single-cell sequencing of polyclonal resistance to FLT3 inhibitors in acute myeloid leukemia (AML). She presents data taken over a period of 28, 48, and 92 days to reveal that NRAS clones were detectable in 0.1% of cells with single-cell analysis at 28 days, which was previously undetectable with bulk sequencing until relapse.

Scientific presentation

Leverage Single-cell Multi-parametric Datasets to Advance Heme Oncology Pipelines

Azad Gucwa, PhD

14th World Clinical Biomarkers & Companion Diagnostics Summit (2024)

Scientific presentation

DKFZ Seminar: Somatic epimutations enable single-cell lineage tracing in native hematopoiesis across the murine and human lifespan

Scientific presentation

DKFZ Seminar: Functional phenotyping of genomic variants using multiomic scDNA-scRNA-seq

Dominik Lindenhofer

Scientific presentation

DKFZ Seminar: Clonal evolution in NPM1c AML

Wout Megchelenbrink

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