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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
Scientific presentation

Single-cell genomics provides new insights into the heterogeneity of CLL

Esteban Braggio, PhD

Dr. Braggio from the Mayo Clinic in Arizona gave a talk at the AACR 2019 meeting, where he looked at several patients with chronic lymphocytic leukemia (CLL) that had complex parallel mutations using single-cell technology. Utilizing Mission Bio’s CLL panel that targets 32 genes implicated in CLL, he discovered diverse mutations underlying the same disease, and he reconstructed the clonality underlying each sample. Moreover, looking at a timecourse series, he showed how the clones expanded and contracted over time. He continues to touch on the patterns and data mapping provided by the Tapestri Platform and how they illuminated mutations that bulk sequencing had previously missed.


Scientific presentation
CHIP’ing away at somatic mosaicism — Diving into the promises and challenges of characterizing clonal hematopoiesis of indeterminate potential
Ross Levine, MD
Kelly Bolton, MD, PhD
Jyoti Nangalia, MD, PhD
Todd Druley, MD, PhD
Scientific presentation
Meet the Authors: Clonal Heterogeneity in Acute Lymphoblastic Leukemia at Diagnosis and During Chemo Treatment
Jan Cools, PhD, VIB Center for Cancer Biology
Scientific presentation
AMP 2021 Corporate Workshop: Single-cell DNA and multi-omics strategies for untangling therapy-resistant mechanisms in oncology
John Lee, M.D., Ph.D., Fred Hutchinson Cancer Research Center & Julia Gouffon, Ph.D., Mission Bio
Association for Molecular Pathology 2021 Digital Experience (2021)
Scientific presentation
Do More Single Cell with Less – Tapestri Platform Expansion for Hematologic Malignancy Research
Koichi Takahashi, MD, PhD, MD Anderson Cancer Center & Jim Flynn, PhD, Mission Bio