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Announcing the new Tapestri Solution for Solid Tumor Oncology Research. Learn More
Scientific presentation

Unraveling clonal heterogeneity and evolutionary history of AML by single-cell DNA sequencing

Koichi Takahashi, MD

Dr. Takahashi from MD Anderson Cancer Center presents his findings using single-cell sequencing from a study of 70 AML patients demonstrating clonal remodeling at relapse. Furthermore, divergent clones with a shared functionality were inferred by reconstructing the phylogeny of driver mutations in AML. Through single-cell analysis, which had 100% concordance with bulk sequencing, he visualized the co-occurrence of foundation mutations to identify cancer driver genes. In this presentation, he shows, through mutation tracking, that clonal heterogeneity is a reflection of how each clone evolves under pressure of the cancer ecosystem and treatment.


Scientific presentation
CHIP’ing away at somatic mosaicism — Diving into the promises and challenges of characterizing clonal hematopoiesis of indeterminate potential
Ross Levine, MD
Kelly Bolton, MD, PhD
Jyoti Nangalia, MD, PhD
Todd Druley, MD, PhD
Scientific presentation
Meet the Authors: Clonal Heterogeneity in Acute Lymphoblastic Leukemia at Diagnosis and During Chemo Treatment
Jan Cools, PhD, VIB Center for Cancer Biology
Scientific presentation
AMP 2021 Corporate Workshop: Single-cell DNA and multi-omics strategies for untangling therapy-resistant mechanisms in oncology
John Lee, M.D., Ph.D., Fred Hutchinson Cancer Research Center & Julia Gouffon, Ph.D., Mission Bio
Association for Molecular Pathology 2021 Digital Experience (2021)
Scientific presentation
Do More Single Cell with Less – Tapestri Platform Expansion for Hematologic Malignancy Research
Koichi Takahashi, MD, PhD, MD Anderson Cancer Center & Jim Flynn, PhD, Mission Bio