Scientific presentation

Precision sequencing with single-cell genomics: resolving heterogeneity in blood and solid tumors

Dennis Eastburn, PhD

Description

The Tapestri Platform provides a single-cell DNA sequencing approach to understand clonal architecture and disease progression. By using microfluidics, each cell is barcoded to reconstruct the genotype of each cell and the clonality of the tumor. The two-step workflow and proprietary multiplex chemistry unlock access to DNA and more, allowing for high-throughput multi-omics analysis of single cells. Each droplet is discretely optimized for each reaction step: isolation of DNA in the first droplet, followed by targeted PCR of the DNA in the second droplet.